|
1
|
Franklin Resources
San Mateo,
California
|
$140M
|
+$4.47M
|
+229,182
|
+3%
|
|
|
2
|
Tang Capital Management
San Diego,
California
|
$112M
|
+$19.6M
|
+1,006,361
|
+19%
|
|
|
3
|
Fidelity Investments
Boston,
Massachusetts
|
$99.2M
|
+$1.25M
|
+63,968
|
+1%
|
|
|
4
|
Janus Henderson Investors US
Denver,
Colorado
|
$72.5M
|
+$10.1M
|
+516,166
|
+15%
|
|
|
5
|
PFM Health Sciences
San Francisco,
California
|
$60.5M
|
+$5.42M
|
+277,634
|
+9%
|
|
|
6
|
|
$52.5M
|
-$4.62M
|
-236,617
|
-8%
|
|
|
7
|
Baker Bros. Advisors
New York
|
$51.6M
|
-$987K
|
-50,534
|
-2%
|
|
|
8
|
Cormorant Asset Management
Boston,
Massachusetts
|
$32M
|
+$415K
|
+21,263
|
+1%
|
|
|
9
|
Broadfin Capital
New York
|
$22.6M
|
-$4.2M
|
-215,371
|
-15%
|
|
|
10
|
Vanguard Group
Malvern,
Pennsylvania
|
$21.9M
|
+$1.13M
|
+58,039
|
+5%
|
|
|
11
|
|
$19.8M
|
–
|
–
|
–
|
|
|
12
|
State Street
Boston,
Massachusetts
|
$17.9M
|
-$4.18M
|
-214,340
|
-18%
|
|
|
13
|
Kingdon Capital Management
New York
|
$16.4M
|
+$9.33M
|
+478,023
|
+110%
|
|
|
14
|
BlackRock Fund Advisors
San Francisco,
California
|
$14.9M
|
+$1.37M
|
+70,177
|
+9%
|
|
|
15
|
BlackRock Institutional Trust
San Francisco,
California
|
$13.6M
|
+$724K
|
+37,108
|
+5%
|
|
|
16
|
Tekla Capital Management
Boston,
Massachusetts
|
$8.89M
|
+$5.34M
|
+273,303
|
+125%
|
|
|
17
|
VHCP Management II
New York
|
$7.33M
|
–
|
–
|
–
|
|
|
18
|
Northern Trust
Chicago,
Illinois
|
$6.44M
|
+$301K
|
+15,395
|
+5%
|
|
|
19
|
|
$6.08M
|
-$230K
|
-11,797
|
-3%
|
|
|
20
|
Brown Advisory
Baltimore,
Maryland
|
$5.56M
|
+$224K
|
+11,471
|
+4%
|
|
|
21
|
Asset Management One
Tokyo,
Japan
|
$5.41M
|
+$419K
|
+21,473
|
+8%
|
|
|
22
|
Panagora Asset Management
Boston,
Massachusetts
|
$4.72M
|
+$311K
|
+15,906
|
+6%
|
|
|
23
|
Geode Capital Management
Boston,
Massachusetts
|
$3.95M
|
+$219K
|
+11,199
|
+5%
|
|
|
24
|
Allianz Asset Management
Munich,
Germany
|
$3.88M
|
-$5.03M
|
-257,787
|
-55%
|
|
|
25
|
Citadel Advisors
Miami,
Florida
|
$3.85M
|
+$3.62M
|
+185,564
|
+664%
|
|
