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Wave Life Sciences

176 hedge funds and large institutions have $903M invested in Wave Life Sciences in 2025 Q2 according to their latest regulatory filings, with 23 funds opening new positions, 84 increasing their positions, 39 reducing their positions, and 40 closing their positions.

New
Increased
Maintained
Reduced
Closed

1,001% more call options, than puts

Call options by funds: $3.37M | Put options by funds: $306K

115% more repeat investments, than reductions

Existing positions increased: 84 | Existing positions reduced: 39

3.71% more ownership

Funds ownership: 85.6%89.31% (+3.7%)

10% less funds holding

Funds holding: 196176 (-20)

15% less capital invested

Capital invested by funds: $1.06B → $903M (-$159M)

25% less funds holding in top 10

Funds holding in top 10: 43 (-1)

43% less first-time investments, than exits

New positions opened: 23 | Existing positions closed: 40

Holders
176
Holders Change
-20
Holders Change %
-10.2%
% of All Funds
2.32%
Holding in Top 10
3
Holding in Top 10 Change
-1
Holding in Top 10 Change %
-25%
% of All Funds
0.04%
New
23
Increased
84
Reduced
39
Closed
40
Calls
$3.37M
Puts
$306K
Net Calls
+$3.06M
Net Calls Change
+$13K
Name Holding Trade Value Shares
Change
Change in
Stake
SPS
51
Susquehanna Portfolio Strategies
Pennsylvania
$1.85M +$1.79M +270,758 +1,890%
DFCM
52
Dark Forest Capital Management
Puerto Rico
$1.82M +$552K +83,549 +42%
CCM
53
Cinctive Capital Management
New York
$1.81M +$1.83M +277,764 New
D.E. Shaw & Co
54
D.E. Shaw & Co
New York
$1.76M +$1.09M +164,920 +155%
Macquarie Group
55
Macquarie Group
Australia
$1.74M -$36.1K -5,470 -2%
N
56
Nuveen
North Carolina
$1.62M +$1.32M +199,266 +397%
FMI
57
F/M Investments
District of Columbia
$1.58M +$21.5K +3,259 +1%
Two Sigma Investments
58
Two Sigma Investments
New York
$1.58M +$9.6K +1,453 +0.6%
Susquehanna International Group
59
Susquehanna International Group
Pennsylvania
$1.46M +$709K +107,337 +92%
Swiss National Bank
60
Swiss National Bank
Switzerland
$1.33M +$87.2K +13,200 +7%
TD Asset Management
61
TD Asset Management
Ontario, Canada
$1.17M +$166K +25,200 +16%
TC
62
TwinBeech Capital
New York
$1.06M -$1.53M -232,303 -59%
Manulife (Manufacturers Life Insurance)
63
Manulife (Manufacturers Life Insurance)
Ontario, Canada
$1.06M +$52.3K +7,913 +5%
RhumbLine Advisers
64
RhumbLine Advisers
Massachusetts
$1.06M +$197K +29,899 +23%
IC
65
Ikarian Capital
Texas
$1.05M +$1.06M +161,137 New
New York State Common Retirement Fund
66
New York State Common Retirement Fund
New York
$978K
Mirae Asset Global ETFs Holdings
67
Mirae Asset Global ETFs Holdings
Hong Kong
$945K +$581K +87,959 +153%
PFM
68
Privium Fund Management
Netherlands
$884K +$145K +22,000 +19%
BFM
69
Boothbay Fund Management
New York
$864K +$569K +86,145 +184%
Wells Fargo
70
Wells Fargo
California
$810K -$649K -98,295 -44%
JJBC
71
James J. Burns & Company
New York
$792K
SI
72
Sofinnova Investments
California
$766K +$779K +117,903 New
Invesco
73
Invesco
Georgia
$747K +$238K +36,079 +46%
ACM
74
ADAR1 Capital Management
Texas
$746K +$606K +91,714 +397%
Legal & General Group
75
Legal & General Group
United Kingdom
$663K -$92.2K -13,962 -12%

WVE Hedge Fund Activity: Q2 2025 in Review

176 of the 7,595 institutional investors tracked by Wall St. Rank reported a position in Wave Life Sciences (WVE) for Q2 2025, worth a combined $903M — down 15% from $1.06B a quarter earlier.

Sellers outnumbered buyers: 40 funds closed out of WVE and 23 opened new positions — a net loss of 17 holders — while 39 trimmed existing stakes and 84 added.

The largest buyer was Adage Capital Partners, adding an estimated $16.5M. The largest seller was Fidelity Investments, cutting an estimated $10.1M.

  • 176 institutional investors held Wave Life Sciences (WVE) as of Q2 2025, down from 196 in Q1 2025.
  • Funds reported $903M of Wave Life Sciences stock for Q2 2025, down 15% quarter-over-quarter.
  • 23 funds opened new Wave Life Sciences positions in Q2 2025 and 40 closed out, a net change of -17 holders.
  • The largest Wave Life Sciences buyer in Q2 2025 was Adage Capital Partners, an estimated $16.5M added.
  • The largest Wave Life Sciences seller in Q2 2025 was Fidelity Investments, an estimated $10.1M sold.

Based on aggregated 13F filings for Q2 2025.