Wave Life Sciences
WVE
218 hedge funds and large institutions have $3.11B invested in Wave Life Sciences in 2025 Q4 according to their latest regulatory filings, with 73 funds opening new positions, 78 increasing their positions, 47 reducing their positions, and 39 closing their positions.
195% more capital invested
Capital invested by funds: $1.05B → $3.11B (+$2.06B)
100% more funds holding in top 10
Funds holding in top 10: 4 → 8 (+4)
87% more first-time investments, than exits
New positions opened: 73 | Existing positions closed: 39
66% more repeat investments, than reductions
Existing positions increased: 78 | Existing positions reduced: 47
18.99% more ownership
Funds ownership: 90.29% → 109.27% (+19%)
16% more call options, than puts
Call options by funds: $50M | Put options by funds: $42.9M
15% more funds holding
Funds holding: 189 → 218 (+29)
Top Buyers
| Rank | Fund | Capital Flow |
|---|---|---|
| 1 |
Fidelity Investments
Boston,
Massachusetts
|
+$102M |
| 2 |
DGM
Darwin Global Management
St. Helier,
Jersey
|
+$74.2M |
| 3 |
T. Rowe Price Associates
Baltimore,
Maryland
|
+$34.2M |
| 4 |
BlackRock
New York
|
+$22.5M |
| 5 |
Primecap Management
Pasadena,
California
|
+$22.3M |
Top Sellers
| Rank | Fund | Capital Flow |
|---|---|---|
| 1 |
Adage Capital Partners
Boston,
Massachusetts
|
-$48.6M |
| 2 |
BG
Bellevue Group
Kuesnacht,
Switzerland
|
-$26.5M |
| 3 |
KCM
Kynam Capital Management
Princeton,
New Jersey
|
-$24.3M |
| 4 |
SC
Stempoint Capital
New York
|
-$15.4M |
| 5 |
SL
Siren LLC
Greenwich,
Connecticut
|
-$12.7M |
WVE Hedge Fund Activity: Q4 2025 in Review
218 of the 8,267 institutional investors tracked by Wall St. Rank reported a position in Wave Life Sciences (WVE) for Q4 2025, worth a combined $3.11B — up 195% from $1.05B a quarter earlier.
Buyers outnumbered sellers: 73 funds opened new WVE positions and 39 closed out — a net gain of 34 holders — while 78 added to existing stakes and 47 trimmed.
The largest buyer was Fidelity Investments, adding an estimated $102M. The largest seller was Adage Capital Partners, cutting an estimated $48.6M.
- 218 institutional investors held Wave Life Sciences (WVE) as of Q4 2025, up from 189 in Q3 2025.
- Funds reported $3.11B of Wave Life Sciences stock for Q4 2025, up 195% quarter-over-quarter.
- 73 funds opened new Wave Life Sciences positions in Q4 2025 and 39 closed out, a net change of +34 holders.
- The largest Wave Life Sciences buyer in Q4 2025 was Fidelity Investments, an estimated $102M added.
- The largest Wave Life Sciences seller in Q4 2025 was Adage Capital Partners, an estimated $48.6M sold.
Based on aggregated 13F filings for Q4 2025.