|
1
|
|
$192M
|
+$15.8M
|
+491,643
|
+9%
|
|
|
2
|
|
$184M
|
–
|
–
|
–
|
|
|
3
|
Fidelity Investments
Boston,
Massachusetts
|
$174M
|
-$2.26M
|
-70,566
|
-1%
|
|
|
4
|
Lynx1 Capital Management
San Juan,
Puerto Rico
|
$132M
|
-$23.3M
|
-725,269
|
-15%
|
|
|
5
|
Redmile Group
San Francisco,
California
|
$129M
|
-$7M
|
-218,200
|
-5%
|
|
|
6
|
Wellington Management Group
Boston,
Massachusetts
|
$115M
|
+$13.6M
|
+423,601
|
+14%
|
|
|
7
|
|
$113M
|
+$947K
|
+29,515
|
+0.9%
|
|
|
8
|
Baker Bros. Advisors
New York
|
$109M
|
–
|
–
|
–
|
|
|
9
|
Toronto Dominion Bank
Toronto, Ontario,
Ontario, Canada
|
$104M
|
–
|
–
|
–
|
|
|
10
|
State Street
Boston,
Massachusetts
|
$93.3M
|
+$18.5M
|
+575,728
|
+25%
|
|
|
11
|
T. Rowe Price Associates
Baltimore,
Maryland
|
$87.1M
|
+$23.3M
|
+727,568
|
+38%
|
|
|
12
|
Vanguard Capital Management
Malvern,
Pennsylvania
|
$84.6M
|
+$7.42M
|
+231,334
|
+10%
|
|
|
13
|
BVF Inc
San Francisco,
California
|
$83.4M
|
–
|
–
|
–
|
|
|
14
|
T. Rowe Price Investment Management
Baltimore,
Maryland
|
$79M
|
+$69.5M
|
+2,164,226
|
+863%
|
|
|
15
|
Siren LLC
Greenwich,
Connecticut
|
$65.3M
|
–
|
–
|
–
|
|
|
16
|
Deerfield Management
New York
|
$59.7M
|
–
|
–
|
–
|
|
|
17
|
|
$59.4M
|
+$58.2M
|
+1,814,408
|
New
|
|
|
18
|
Geode Capital Management
Boston,
Massachusetts
|
$49.9M
|
+$6.48M
|
+202,049
|
+15%
|
|
|
19
|
Assenagon Asset Management
Senningerberg,
Luxembourg
|
$36.9M
|
+$7.1M
|
+221,373
|
+24%
|
|
|
20
|
Dimensional Fund Advisors
Austin,
Texas
|
$33.2M
|
+$769K
|
+23,975
|
+2%
|
|
|
21
|
Polar Capital Holdings
London,
United Kingdom
|
$27.3M
|
-$9.59M
|
-298,795
|
-26%
|
|
|
22
|
EcoR1 Capital
San Francisco,
California
|
$24M
|
+$20.4M
|
+635,000
|
+635%
|
|
|
23
|
MPM BioImpact
Boston,
Massachusetts
|
$23.7M
|
-$1.4M
|
-43,724
|
-6%
|
|
|
24
|
Opaleye Management
Boston,
Massachusetts
|
$22.9M
|
–
|
–
|
–
|
|
|
25
|
|
$18.8M
|
-$8.2M
|
-255,358
|
-31%
|
|
