|
1
|
Fidelity Investments
Boston,
Massachusetts
|
$161M
|
-$9.39M
|
-547,925
|
-7%
|
|
|
2
|
|
$141M
|
+$1.08M
|
+62,874
|
+1%
|
|
|
3
|
|
$120M
|
–
|
–
|
–
|
|
|
4
|
Lynx1 Capital Management
San Juan,
Puerto Rico
|
$110M
|
–
|
–
|
–
|
|
|
5
|
Baker Bros. Advisors
New York
|
$109M
|
–
|
–
|
–
|
|
|
6
|
Redmile Group
San Francisco,
California
|
$98.1M
|
-$3.43M
|
-200,389
|
-5%
|
|
|
7
|
|
$83.1M
|
-$633K
|
-36,926
|
-1%
|
|
|
8
|
Toronto Dominion Bank
Toronto, Ontario,
Ontario, Canada
|
$74.6M
|
–
|
–
|
–
|
|
|
9
|
Vanguard Group
Malvern,
Pennsylvania
|
$74.4M
|
+$3.73M
|
+217,616
|
+7%
|
|
|
10
|
Skorpios Trust
Limassol,
Cyprus
|
$53M
|
-$17.1M
|
-1,000,000
|
-31%
|
|
|
11
|
Siren LLC
Greenwich,
Connecticut
|
$52.8M
|
–
|
–
|
–
|
|
|
12
|
BVF Inc
San Francisco,
California
|
$38.9M
|
+$28.4M
|
+1,657,096
|
New
|
|
|
13
|
State Street
Boston,
Massachusetts
|
$33.5M
|
-$1.05M
|
-61,283
|
-4%
|
|
|
14
|
Polar Capital Holdings
London,
United Kingdom
|
$31.1M
|
+$7.54M
|
+439,824
|
+50%
|
|
|
15
|
Point72 Asset Management
Stamford,
Connecticut
|
$30.7M
|
+$22.4M
|
+1,306,698
|
New
|
|
|
16
|
|
$27M
|
-$2.58M
|
-150,452
|
-12%
|
|
|
17
|
Geode Capital Management
Boston,
Massachusetts
|
$27M
|
+$2.98M
|
+174,079
|
+18%
|
|
|
18
|
Royal Bank of Canada
Toronto,
Ontario, Canada
|
$21.5M
|
+$13.2M
|
+771,722
|
+536%
|
|
|
19
|
Assenagon Asset Management
Senningerberg,
Luxembourg
|
$21.2M
|
+$6.21M
|
+362,299
|
+67%
|
|
|
20
|
MPM BioImpact
Boston,
Massachusetts
|
$18.6M
|
–
|
–
|
–
|
|
|
21
|
Marshall Wace
London,
United Kingdom
|
$18.1M
|
-$26.3M
|
-1,532,267
|
-67%
|
|
|
22
|
Wellington Management Group
Boston,
Massachusetts
|
$17.3M
|
+$10.3M
|
+600,687
|
+438%
|
|
|
23
|
Opaleye Management
Boston,
Massachusetts
|
$16M
|
+$2.05M
|
+119,897
|
+21%
|
|
|
24
|
Dimensional Fund Advisors
Austin,
Texas
|
$15.9M
|
+$75.8K
|
+4,423
|
+0.7%
|
|
|
25
|
Tang Capital Management
San Diego,
California
|
$11.8M
|
–
|
–
|
–
|
|
