|
1
|
|
$183M
|
+$2.51M
|
+76,669
|
+1%
|
|
|
2
|
|
$175M
|
+$5.68M
|
+173,160
|
+3%
|
|
|
3
|
Fidelity Investments
Boston,
Massachusetts
|
$175M
|
-$7.12M
|
-217,254
|
-4%
|
|
|
4
|
Lynx1 Capital Management
San Juan,
Puerto Rico
|
$155M
|
-$21M
|
-641,001
|
-12%
|
|
|
5
|
Redmile Group
San Francisco,
California
|
$136M
|
+$4.27M
|
+130,050
|
+3%
|
|
|
6
|
|
$111M
|
-$4.03M
|
-122,878
|
-3%
|
|
|
7
|
Baker Bros. Advisors
New York
|
$109M
|
–
|
–
|
–
|
|
|
8
|
Toronto Dominion Bank
Toronto, Ontario,
Ontario, Canada
|
$103M
|
–
|
–
|
–
|
|
|
9
|
Wellington Management Group
Boston,
Massachusetts
|
$101M
|
+$77.4M
|
+2,359,901
|
+321%
|
|
|
10
|
BVF Inc
San Francisco,
California
|
$82.9M
|
+$9.24M
|
+281,883
|
+12%
|
|
|
11
|
Vanguard Capital Management
Malvern,
Pennsylvania
|
$76.7M
|
+$77.3M
|
+2,355,603
|
New
|
|
|
12
|
State Street
Boston,
Massachusetts
|
$74.1M
|
-$7.27M
|
-221,537
|
-9%
|
|
|
13
|
Siren LLC
Greenwich,
Connecticut
|
$65M
|
-$8.26M
|
-252,000
|
-11%
|
|
|
14
|
T. Rowe Price Associates
Baltimore,
Maryland
|
$63M
|
+$51.2M
|
+1,561,837
|
+419%
|
|
|
15
|
Deerfield Management
New York
|
$59.4M
|
–
|
–
|
–
|
|
|
16
|
Janus Henderson Group
London,
|
$52.5M
|
+$5.31M
|
+161,848
|
+11%
|
|
|
17
|
Geode Capital Management
Boston,
Massachusetts
|
$43.1M
|
+$5.12M
|
+156,115
|
+13%
|
|
|
18
|
Polar Capital Holdings
London,
United Kingdom
|
$36.9M
|
-$4.48M
|
-136,620
|
-11%
|
|
|
19
|
Dimensional Fund Advisors
Austin,
Texas
|
$32.2M
|
+$5.34M
|
+162,797
|
+20%
|
|
|
20
|
Assenagon Asset Management
Senningerberg,
Luxembourg
|
$29.5M
|
-$10.5M
|
-320,708
|
-26%
|
|
|
21
|
|
$27M
|
-$10.2M
|
-312,035
|
-27%
|
|
|
22
|
MPM BioImpact
Boston,
Massachusetts
|
$25M
|
-$107K
|
-3,251
|
-0.4%
|
|
|
23
|
Opaleye Management
Boston,
Massachusetts
|
$22.8M
|
+$164K
|
+5,000
|
+0.7%
|
|
|
24
|
Troluce Capital Advisors
Dorado,
Puerto Rico
|
$21.3M
|
+$21.4M
|
+652,800
|
New
|
|
|
25
|
Baillie Gifford & Co
Edinburgh,
United Kingdom
|
$18.7M
|
+$10.8M
|
+328,282
|
+133%
|
|
