|
1
|
Fidelity Investments
Boston,
Massachusetts
|
$178M
|
-$38M
|
-1,264,137
|
-18%
|
|
|
2
|
|
$176M
|
+$12.7M
|
+423,331
|
+8%
|
|
|
3
|
Lynx1 Capital Management
San Juan,
Puerto Rico
|
$172M
|
–
|
–
|
–
|
|
|
4
|
|
$165M
|
-$23.3M
|
-774,887
|
-13%
|
|
|
5
|
Redmile Group
San Francisco,
California
|
$128M
|
-$4.25M
|
-141,472
|
-3%
|
|
|
6
|
|
$113M
|
+$274K
|
+9,108
|
+0.3%
|
|
|
7
|
Baker Bros. Advisors
New York
|
$106M
|
-$39M
|
-1,297,141
|
-28%
|
|
|
8
|
Toronto Dominion Bank
Toronto, Ontario,
Ontario, Canada
|
$101M
|
–
|
–
|
–
|
|
|
9
|
Vanguard Group
Malvern,
Pennsylvania
|
$100M
|
-$440K
|
-14,635
|
-0.5%
|
|
|
10
|
State Street
Boston,
Massachusetts
|
$79.3M
|
+$32.2M
|
+1,072,176
|
+75%
|
|
|
11
|
BVF Inc
San Francisco,
California
|
$71.9M
|
+$18.3M
|
+608,578
|
+37%
|
|
|
12
|
Siren LLC
Greenwich,
Connecticut
|
$71.3M
|
–
|
–
|
–
|
|
|
13
|
Deerfield Management
New York
|
$57.9M
|
+$54.8M
|
+1,823,500
|
New
|
|
|
14
|
Janus Henderson Group
London,
|
$46M
|
+$33.6M
|
+1,116,452
|
+334%
|
|
|
15
|
Polar Capital Holdings
London,
United Kingdom
|
$40.3M
|
-$1.63M
|
-54,339
|
-4%
|
|
|
16
|
Assenagon Asset Management
Senningerberg,
Luxembourg
|
$39M
|
+$9.84M
|
+327,451
|
+36%
|
|
|
17
|
Point72 Asset Management
Stamford,
Connecticut
|
$38.8M
|
-$2.54M
|
-84,485
|
-6%
|
|
|
18
|
Geode Capital Management
Boston,
Massachusetts
|
$37M
|
+$576K
|
+19,145
|
+2%
|
|
|
19
|
|
$36.3M
|
-$246K
|
-8,192
|
-0.7%
|
|
|
20
|
Dimensional Fund Advisors
Austin,
Texas
|
$26.3M
|
+$4.47M
|
+148,832
|
+22%
|
|
|
21
|
MPM BioImpact
Boston,
Massachusetts
|
$24.4M
|
-$583K
|
-19,409
|
-2%
|
|
|
22
|
Wellington Management Group
Boston,
Massachusetts
|
$23.4M
|
-$58.7K
|
-1,954
|
-0.3%
|
|
|
23
|
Opaleye Management
Boston,
Massachusetts
|
$22.1M
|
+$390K
|
+12,983
|
+2%
|
|
|
24
|
Tang Capital Management
San Diego,
California
|
$15.9M
|
–
|
–
|
–
|
|
|
25
|
Candriam SCA
Strassen, Luxembourg,
Luxembourg
|
$14.2M
|
+$13.4M
|
+446,690
|
New
|
|
