|
1
|
Fidelity Investments
Boston,
Massachusetts
|
$84.1M
|
+$46.2M
|
+4,871,045
|
+192%
|
|
|
2
|
|
$67.2M
|
+$590K
|
+62,131
|
+1%
|
|
|
3
|
Lynx1 Capital Management
San Juan,
Puerto Rico
|
$61.3M
|
+$1.07M
|
+112,745
|
+2%
|
|
|
4
|
|
$58.2M
|
–
|
–
|
–
|
|
|
5
|
Baker Bros. Advisors
New York
|
$52.6M
|
–
|
–
|
–
|
|
|
6
|
Redmile Group
San Francisco,
California
|
$49.7M
|
-$1.04M
|
-110,050
|
-2%
|
|
|
7
|
|
$40.6M
|
-$160K
|
-16,849
|
-0.5%
|
|
|
8
|
Skorpios Trust
Limassol,
Cyprus
|
$37M
|
-$34.7M
|
-3,650,000
|
-53%
|
|
|
9
|
Toronto Dominion Bank
Toronto, Ontario,
Ontario, Canada
|
$36M
|
–
|
–
|
–
|
|
|
10
|
Vanguard Group
Malvern,
Pennsylvania
|
$33.4M
|
+$1.54M
|
+162,056
|
+6%
|
|
|
11
|
Marshall Wace
London,
United Kingdom
|
$26.1M
|
+$1.6M
|
+168,771
|
+8%
|
|
|
12
|
Siren LLC
Greenwich,
Connecticut
|
$25.5M
|
–
|
–
|
–
|
|
|
13
|
State Street
Boston,
Massachusetts
|
$16.9M
|
-$837K
|
-88,127
|
-6%
|
|
|
14
|
|
$14.8M
|
-$3.42M
|
-360,658
|
-22%
|
|
|
15
|
Geode Capital Management
Boston,
Massachusetts
|
$11M
|
+$674K
|
+70,935
|
+8%
|
|
|
16
|
Polar Capital Holdings
London,
United Kingdom
|
$10M
|
+$8.39M
|
+883,646
|
New
|
|
|
17
|
MPM BioImpact
Boston,
Massachusetts
|
$8.96M
|
+$909K
|
+95,710
|
+14%
|
|
|
18
|
Dimensional Fund Advisors
Austin,
Texas
|
$7.65M
|
+$86.9K
|
+9,149
|
+1%
|
|
|
19
|
Corient Private Wealth
Miami,
Florida
|
$7.49M
|
+$6.26M
|
+659,834
|
New
|
|
|
20
|
Opaleye Management
Boston,
Massachusetts
|
$6.38M
|
+$2.49M
|
+262,120
|
+87%
|
|
|
21
|
Bank of America
Charlotte,
North Carolina
|
$6.22M
|
+$144K
|
+15,206
|
+3%
|
|
|
22
|
Assenagon Asset Management
Senningerberg,
Luxembourg
|
$6.11M
|
-$4M
|
-421,630
|
-44%
|
|
|
23
|
Granahan Investment Management
Waltham,
Massachusetts
|
$6.04M
|
-$1.22M
|
-128,017
|
-19%
|
|
|
24
|
DAFNA Capital Management
Los Angeles,
California
|
$5.7M
|
+$550K
|
+57,974
|
+13%
|
|
|
25
|
Tang Capital Management
San Diego,
California
|
$5.67M
|
–
|
–
|
–
|
|
