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Rhythm Pharmaceuticals
RYTM

285 hedge funds and large institutions have $6.42B invested in Rhythm Pharmaceuticals in 2026 Q1 according to their latest regulatory filings, with 64 funds opening new positions, 101 increasing their positions, 89 reducing their positions, and 51 closing their positions.

New
Increased
Maintained
Reduced
Closed

776% more call options, than puts

Call options by funds: $16.4M | Put options by funds: $1.87M

25% more first-time investments, than exits

New positions opened: 64 | Existing positions closed: 51

13% more repeat investments, than reductions

Existing positions increased: 101 | Existing positions reduced: 89

2% more funds holding

Funds holding: 279 → 285 (+6)

0% more funds holding in top 10

Funds holding in top 10: 10 → 10 (0)

1.43% less ownership

Funds ownership: 109.17% → 107.74% (-1.4%)

18% less capital invested

Capital invested by funds: $7.8B → $6.42B (-$1.38B)

Holders
285
Holders Change
+6
Holders Change %
+2.15%
% of All Funds
3.51%
Holding in Top 10
10
Holding in Top 10 Change
–
Holding in Top 10 Change %
–
% of All Funds
0.12%
New
64
Increased
101
Reduced
89
Closed
51
Calls
$16.4M
Puts
$1.87M
Net Calls
+$14.5M
Net Calls Change
+$1.06M

Top Buyers

1
Citadel Advisors
Citadel Advisors
Florida
+$123M
2
Westfield Capital Management
Westfield Capital Management
Massachusetts
+$64.4M
3
PCH
Polar Capital Holdings
United Kingdom
+$41.8M
4
Point72 Asset Management
Point72 Asset Management
Connecticut
+$40.6M
5
Bank of America
Bank of America
North Carolina
+$39.3M

Top Sellers

1
NMC
NEA Management Company
Maryland
-$311M
2
Jennison Associates
Jennison Associates
New York
-$98.3M
3
DCM
Driehaus Capital Management
Illinois
-$82.5M
4
Federated Hermes
Federated Hermes
Pennsylvania
-$32.8M
5
Lord, Abbett & Co
Lord, Abbett & Co
New Jersey
-$26.3M
Name Holding Trade Value Shares
Change 		Change in
Stake
LMGAM
126
Liberty Mutual Group Asset Management
Massachusetts
$1.78M +$1.99M +20,514 New
Victory Capital Management
127
Victory Capital Management
Texas
$1.78M -$2.42M -24,877 -55%
Tudor Investment Corp
128
Tudor Investment Corp
Connecticut
$1.71M +$1.91M +19,646 New
State of New Jersey Common Pension Fund D
129
State of New Jersey Common Pension Fund D
New Jersey
$1.69M +$11.3K +116 +0.6%
Dimensional Fund Advisors
130
Dimensional Fund Advisors
Texas
$1.67M -$1.25M -12,867 -40%
SG Americas Securities
131
SG Americas Securities
New York
$1.63M +$683K +7,019 +60%
AAM
132
Advisors Asset Management
Colorado
$1.63M +$18.9K +194 +1%
CAPTRUST Financial Advisors
133
CAPTRUST Financial Advisors
North Carolina
$1.58M -$17.3K -178 -1%
ECM
134
ExodusPoint Capital Management
New York
$1.55M -$5.58M -57,366 -76%
Handelsbanken Fonder
135
Handelsbanken Fonder
Sweden
$1.52M – – –
HS
136
HighVista Strategies
Massachusetts
$1.46M -$2.54M -26,071 -61%
GC
137
Guggenheim Capital
Illinois
$1.44M +$404K +4,153 +33%
Zurich Cantonal Bank
138
Zurich Cantonal Bank
Switzerland
$1.36M +$1.52M +15,598 New
KOCAA
139
Knights of Columbus Asset Advisors
Connecticut
$1.36M +$513K +5,275 +51%
ASRS
140
Arizona State Retirement System
Arizona
$1.36M -$17.6K -181 -1%
State Board of Administration of Florida Retirement System
141
State Board of Administration of Florida Retirement System
Florida
$1.27M – – –
PFSRSONJ
142
Police & Firemen's Retirement System of New Jersey
New Jersey
$1.27M +$40K +411 +3%
HSBC Holdings
143
HSBC Holdings
United Kingdom
$1.22M +$1.39M +14,307 New
VIA
144
Vanguard Investments Australia
Australia
$1.21M +$1.35M +13,927 New
JRP
145
Jasper Ridge Partners
California
$1.2M +$798K +8,206 +146%
IIM
146
INTECH Investment Management
Florida
$1.19M -$740K -7,611 -36%
KK
147
KLP Kapitalforvaltning
Norway
$1.09M +$48.6K +500 +4%
BC
148
Bridgefront Capital
Texas
$1.09M +$1.22M +12,495 New
Stifel Financial
149
Stifel Financial
Missouri
$1.07M -$88.3K -908 -7%
Citigroup
150
Citigroup
New York
$1.07M -$37.3K -384 -3%
4 5
6
7 8

RYTM Hedge Fund Activity: Q1 2026 in Review

285 of the 8,126 institutional investors tracked by Wall St. Rank reported a position in Rhythm Pharmaceuticals (RYTM) for Q1 2026, worth a combined $6.42B — down 18% from $7.8B a quarter earlier.

Buyers outnumbered sellers: 64 funds opened new RYTM positions and 51 closed out — a net gain of 13 holders — while 101 added to existing stakes and 89 trimmed.

The largest buyer was Citadel Advisors, adding an estimated $123M. The largest seller was NEA Management Company, exiting entirely with an estimated $311M sold.

  • 285 institutional investors held Rhythm Pharmaceuticals (RYTM) as of Q1 2026, up from 279 in Q4 2025.
  • Funds reported $6.42B of Rhythm Pharmaceuticals stock for Q1 2026, down 18% quarter-over-quarter.
  • 64 funds opened new Rhythm Pharmaceuticals positions in Q1 2026 and 51 closed out, a net change of +13 holders.
  • The largest Rhythm Pharmaceuticals buyer in Q1 2026 was Citadel Advisors, an estimated $123M added.
  • The largest Rhythm Pharmaceuticals seller in Q1 2026 was NEA Management Company, an estimated $311M sold.

Based on aggregated 13F filings for Q1 2026.