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Rhythm Pharmaceuticals
RYTM

285 hedge funds and large institutions have $6.42B invested in Rhythm Pharmaceuticals in 2026 Q1 according to their latest regulatory filings, with 64 funds opening new positions, 101 increasing their positions, 89 reducing their positions, and 51 closing their positions.

New
Increased
Maintained
Reduced
Closed

776% more call options, than puts

Call options by funds: $16.4M | Put options by funds: $1.87M

25% more first-time investments, than exits

New positions opened: 64 | Existing positions closed: 51

13% more repeat investments, than reductions

Existing positions increased: 101 | Existing positions reduced: 89

2% more funds holding

Funds holding: 279 → 285 (+6)

0% more funds holding in top 10

Funds holding in top 10: 10 → 10 (0)

1.43% less ownership

Funds ownership: 109.17% → 107.74% (-1.4%)

18% less capital invested

Capital invested by funds: $7.8B → $6.42B (-$1.38B)

Holders
285
Holders Change
+6
Holders Change %
+2.15%
% of All Funds
3.51%
Holding in Top 10
10
Holding in Top 10 Change
–
Holding in Top 10 Change %
–
% of All Funds
0.12%
New
64
Increased
101
Reduced
89
Closed
51
Calls
$16.4M
Puts
$1.87M
Net Calls
+$14.5M
Net Calls Change
+$1.06M

Top Buyers

1
Citadel Advisors
Citadel Advisors
Florida
+$123M
2
Westfield Capital Management
Westfield Capital Management
Massachusetts
+$64.4M
3
PCH
Polar Capital Holdings
United Kingdom
+$41.8M
4
Point72 Asset Management
Point72 Asset Management
Connecticut
+$40.6M
5
Bank of America
Bank of America
North Carolina
+$39.3M

Top Sellers

1
NMC
NEA Management Company
Maryland
-$311M
2
Jennison Associates
Jennison Associates
New York
-$98.3M
3
DCM
Driehaus Capital Management
Illinois
-$82.5M
4
Federated Hermes
Federated Hermes
Pennsylvania
-$32.8M
5
Lord, Abbett & Co
Lord, Abbett & Co
New Jersey
-$26.3M
Name Holding Trade Value Shares
Change 		Change in
Stake
Bank of New York Mellon
51
Bank of New York Mellon
New York
$25.5M -$757K -7,782 -3%
Qube Research & Technologies (QRT)
52
Qube Research & Technologies (QRT)
United Kingdom
$24.2M -$3.21M -32,976 -11%
Wellington Management Group
53
Wellington Management Group
Massachusetts
$23.8M +$2.3M +23,601 +9%
Squarepoint
54
Squarepoint
New York
$22.9M +$22.4M +230,139 +701%
Renaissance Technologies
55
Renaissance Technologies
New York
$22.4M -$8.09M -83,182 -24%
BNP Paribas Financial Markets
56
BNP Paribas Financial Markets
France
$21.6M +$8.1M +83,313 +51%
HRCM
57
Hood River Capital Management
Florida
$20.9M +$279K +2,869 +1%
VOYA Investment Management
58
VOYA Investment Management
Georgia
$20.3M -$1.56M -16,064 -6%
UBS Group
59
UBS Group
Switzerland
$20.1M -$19M -195,586 -46%
ACM
60
ADAR1 Capital Management
Texas
$18.4M +$15.6M +160,101 +312%
SC
61
SummitTX Capital
Texas
$14.4M +$8.25M +84,870 +105%
Connor, Clark & Lunn Investment Management (CC&L)
62
Connor, Clark & Lunn Investment Management (CC&L)
British Columbia, Canada
$13.2M +$240K +2,469 +2%
Deutsche Bank
63
Deutsche Bank
Germany
$12.3M +$1.21M +12,478 +10%
MGP
64
M&G plc
United Kingdom
$12.1M +$145K +1,493 +1%
PHS
65
PFM Health Sciences
California
$11.9M +$9.38M +96,411 +240%
NCM
66
NEXTBio Capital Management
California
$11M +$5.69M +58,492 +87%
New York State Common Retirement Fund
67
New York State Common Retirement Fund
New York
$10.9M +$3.07M +31,530 +34%
N
68
Nuveen
North Carolina
$10.2M +$140K +1,442 +1%
Schroder Investment Management Group
69
Schroder Investment Management Group
United Kingdom
$10.2M +$12.8M +131,674 New
Russell Investments Group
70
Russell Investments Group
United Kingdom
$10.1M -$1.8M -18,468 -14%
Capital World Investors
71
Capital World Investors
California
$10.1M – – –
Swiss National Bank
72
Swiss National Bank
Switzerland
$9.76M +$87.5K +900 +0.8%
AI
73
Axiom Investors
Connecticut
$7.98M +$797K +8,195 +10%
FLAM
74
First Light Asset Management
Minnesota
$7.58M -$20.3M -208,663 -71%
First Trust Advisors
75
First Trust Advisors
Illinois
$7.44M -$292K -2,999 -3%
1 2
3
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RYTM Hedge Fund Activity: Q1 2026 in Review

285 of the 8,126 institutional investors tracked by Wall St. Rank reported a position in Rhythm Pharmaceuticals (RYTM) for Q1 2026, worth a combined $6.42B — down 18% from $7.8B a quarter earlier.

Buyers outnumbered sellers: 64 funds opened new RYTM positions and 51 closed out — a net gain of 13 holders — while 101 added to existing stakes and 89 trimmed.

The largest buyer was Citadel Advisors, adding an estimated $123M. The largest seller was NEA Management Company, exiting entirely with an estimated $311M sold.

  • 285 institutional investors held Rhythm Pharmaceuticals (RYTM) as of Q1 2026, up from 279 in Q4 2025.
  • Funds reported $6.42B of Rhythm Pharmaceuticals stock for Q1 2026, down 18% quarter-over-quarter.
  • 64 funds opened new Rhythm Pharmaceuticals positions in Q1 2026 and 51 closed out, a net change of +13 holders.
  • The largest Rhythm Pharmaceuticals buyer in Q1 2026 was Citadel Advisors, an estimated $123M added.
  • The largest Rhythm Pharmaceuticals seller in Q1 2026 was NEA Management Company, an estimated $311M sold.

Based on aggregated 13F filings for Q1 2026.