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QURE

Name Holding Trade Value Shares
Change 		Change in
Stake
Adage Capital Partners
26
Adage Capital Partners
Massachusetts
$12.6M – – –
Millennium Management
27
Millennium Management
New York
$11.6M +$12.7M +302,229 +1,572%
Geode Capital Management
28
Geode Capital Management
Massachusetts
$11.5M -$179K -4,247 -1%
FCM
29
Farallon Capital Management
California
$10.8M -$6.33M -150,000 -33%
BC
30
Boxer Capital
California
$9.03M -$21.7M -515,400 -67%
CAM
31
Cormorant Asset Management
Massachusetts
$9.03M -$3.16M -75,000 -23%
Renaissance Technologies
32
Renaissance Technologies
New York
$8.02M +$9.36M +221,940 New
SFM
33
Sphera Funds Management
Israel
$7.8M +$3.8M +90,000 +71%
RSCM
34
Rock Springs Capital Management
Maryland
$7.53M -$8.64M -204,933 -50%
Charles Schwab
35
Charles Schwab
California
$6.1M +$96.1K +2,279 +1%
CC
36
Carlson Capital
Texas
$5.88M -$650K -15,400 -9%
Susquehanna International Group
37
Susquehanna International Group
Pennsylvania
$5.82M -$968K -22,941 -12%
Hudson Bay Capital Management
38
Hudson Bay Capital Management
Connecticut
$5.33M -$2.85M -67,600 -31%
PF
39
Phoenix Financial
Israel
$4.96M +$844K +20,000 +17%
TCM
40
Tekla Capital Management
Massachusetts
$4.52M +$2.61M +61,964 +98%
HT
41
HAP Trading
New York
$4.46M -$128K -3,032 -2%
HJIM
42
Henry James International Management
New York
$4.45M +$591 +14 +0%
MS
43
Maven Securities
Jersey
$4.31M +$4.9M +116,085 New
California Public Employees Retirement System
44
California Public Employees Retirement System
California
$3.39M +$357K +8,465 +10%
Group One Trading
45
Group One Trading
Illinois
$3.26M +$636K +15,069 +20%
Two Sigma Advisers
46
Two Sigma Advisers
New York
$3.17M -$1.11M -26,400 -23%
AA
47
ALPS Advisors
Colorado
$2.9M +$998K +23,657 +42%
Northern Trust
48
Northern Trust
Illinois
$2.88M -$102K -2,409 -3%
CM
49
Caption Management
Oklahoma
$2.86M -$2.15M -50,906 -39%
Envestnet Asset Management
50
Envestnet Asset Management
Illinois
$2.78M +$287K +6,792 +10%
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