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QURE

Name Holding Trade Value Shares
Change 		Change in
Stake
Fidelity Investments
1
Fidelity Investments
Massachusetts
$20.6M -$7.88M -533,651 -24%
PA
2
Perceptive Advisors
New York
$17.1M +$7.01M +475,000 +49%
SAM
3
Sectoral Asset Management
Quebec, Canada
$17M +$4.26M +288,800 +25%
PC
4
Passport Capital
California
$4.75M +$5.91M +400,000 New
PI
5
Putnam Investments
Massachusetts
$4.14M +$16.2K +1,097 +0.3%
UBS AM
6
UBS AM
Illinois
$4.1M +$278K +18,803 +6%
SIM
7
Spark Investment Management
New York
$3.52M +$958K +64,900 +28%
BFA
8
BlackRock Fund Advisors
California
$3.49M +$412K +27,903 +10%
Point72 Asset Management
9
Point72 Asset Management
Connecticut
$3.25M -$2.83M -191,972 -41%
TCM
10
Tekla Capital Management
Massachusetts
$2.86M +$968K +65,521 +37%
Bank of America
11
Bank of America
North Carolina
$2.82M +$3.39M +229,867 +3,049%
BBA
12
Baker Bros. Advisors
New York
$2.73M +$2.95M +200,000 +667%
Renaissance Technologies
13
Renaissance Technologies
New York
$2.44M +$1.49M +100,600 +96%
O
14
OrbiMed
New York
$2.19M +$2.73M +184,800 New
EAM
15
Eventide Asset Management
Massachusetts
$2.08M – – –
DCM
16
DAFNA Capital Management
California
$1.89M +$1.83M +123,907 +354%
Deutsche Bank
17
Deutsche Bank
Germany
$1.87M +$676K +45,768 +41%
LCM
18
Landscape Capital Management
New Jersey
$1.83M +$1.71M +115,975 +304%
NC
19
Nexthera Capital
New York
$1.37M +$1.17M +79,000 +219%
GIP
20
Granite Investment Partners
California
$1.14M -$2.24M -151,504 -61%
Macquarie Group
21
Macquarie Group
Australia
$1M +$1.25M +84,400 New
TAM
22
Tocqueville Asset Management
New York
$947K – – –
Millennium Management
23
Millennium Management
New York
$716K -$3.58M -242,628 -80%
Capital Fund Management (CFM)
24
Capital Fund Management (CFM)
France
$508K +$467K +31,595 +282%
DC
25
Deere & Company
Illinois
$460K +$191K +12,912 +50%
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