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QURE

Name Holding Trade Value Shares
Change 		Change in
Stake
Fidelity Investments
1
Fidelity Investments
Massachusetts
$46.5M +$3.4M +128,973 +6%
SAM
2
Sectoral Asset Management
Quebec, Canada
$15.6M +$2.95M +112,113 +17%
PA
3
Perceptive Advisors
New York
$14.1M +$1.05M +40,000 +6%
Point72 Asset Management
4
Point72 Asset Management
Connecticut
$11.4M +$247K +9,389 +2%
EAM
5
EverPoint Asset Management
Connecticut
$9.51M +$7.64M +290,000 +166%
Millennium Management
6
Millennium Management
New York
$9.29M +$2.82M +107,080 +31%
PI
7
Putnam Investments
Massachusetts
$7.12M +$38.8K +1,474 +0.4%
UBS AM
8
UBS AM
Illinois
$6.68M – – –
GIP
9
Granite Investment Partners
California
$5.38M +$1.51M +57,439 +28%
Balyasny Asset Management
10
Balyasny Asset Management
Illinois
$3.52M +$4.54M +172,292 New
EAM
11
Eventide Asset Management
Massachusetts
$3.17M +$1.7M +64,400 +71%
GTC
12
Ghost Tree Capital
New York
$3.07M -$922K -35,000 -19%
NI
13
Numeric Investors
Massachusetts
$2.46M +$3.17M +120,508 New
SFM
14
Sphera Funds Management
Israel
$2.35M – – –
TCM
15
Tekla Capital Management
Massachusetts
$2.1M +$2.71M +102,800 New
Lord, Abbett & Co
16
Lord, Abbett & Co
New Jersey
$1.83M -$3.37M -128,071 -59%
WSA
17
Wall Street Associates
California
$1.73M +$780K +29,600 +54%
TAM
18
Tocqueville Asset Management
New York
$1.54M +$75.1K +2,850 +4%
Deutsche Bank
19
Deutsche Bank
Germany
$1.5M +$873K +33,145 +83%
PP
20
PDT Partners
New York
$1.24M +$195K +7,392 +14%
Susquehanna International Group
21
Susquehanna International Group
Pennsylvania
$1.12M +$829K +31,493 +135%
D.E. Shaw & Co
22
D.E. Shaw & Co
New York
$1.02M +$652K +24,738 +99%
Citadel Advisors
23
Citadel Advisors
Florida
$843K +$202K +7,657 +23%
HCM
24
Harvey Capital Management
Florida
$827K -$79K -3,000 -7%
DCM
25
DAFNA Capital Management
California
$716K -$132K -5,000 -13%
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