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QURE

Name Holding Trade Value Shares
Change 		Change in
Stake
Fidelity Investments
1
Fidelity Investments
Massachusetts
$42.8M -$851 -39 -0%
PA
2
Perceptive Advisors
New York
$25.2M +$18.4M +843,476 +431%
TCP
3
Tourbillon Capital Partners
New York
$7.3M +$6.54M +300,000 New
GIP
4
Granite Investment Partners
California
$5.9M +$3.86M +177,173 +270%
ACA
5
Avoro Capital Advisors
New York
$5.51M +$4.94M +226,456 New
Millennium Management
6
Millennium Management
New York
$4.75M +$1.11M +51,097 +35%
O
7
OppenheimerFunds
New York
$3.86M +$3.46M +158,720 New
SFM
8
Sphera Funds Management
Israel
$2.49M -$1.44M -66,000 -39%
PI
9
Putnam Investments
Massachusetts
$2.34M – – –
EAM
10
Eventide Asset Management
Massachusetts
$2.2M +$903K +41,400 +84%
First Eagle Investment Management
11
First Eagle Investment Management
New York
$2.17M -$5.73M -262,700 -75%
Morgan Stanley
12
Morgan Stanley
New York
$1.73M +$1.08M +49,623 +231%
CC
13
CQS Cayman
Cayman Islands
$1.45M +$1.3M +59,400 New
WSA
14
Wall Street Associates
California
$1.34M – – –
SIM
15
Spark Investment Management
New York
$1.25M +$766K +35,100 +210%
Northern Trust
16
Northern Trust
Illinois
$920K +$825K +37,829 New
EI
17
EAM Investors
California
$800K +$718K +32,914 New
DCM
18
DAFNA Capital Management
California
$730K -$211K -9,656 -24%
BBA
19
Baker Bros. Advisors
New York
$730K -$14.7K -672 -2%
Deutsche Bank
20
Deutsche Bank
Germany
$729K -$1.07M -48,958 -62%
Bank of New York Mellon
21
Bank of New York Mellon
New York
$721K +$647K +29,661 New
CCI
22
Columbus Circle Investors
$707K -$3.34M -153,122 -84%
HCM
23
Harvey Capital Management
Florida
$537K +$482K +22,100 New
New York State Common Retirement Fund
24
New York State Common Retirement Fund
New York
$521K +$468K +21,439 New
Balyasny Asset Management
25
Balyasny Asset Management
Illinois
$512K +$459K +21,038 New
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