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QURE

Name Holding Trade Value Shares
Change 		Change in
Stake
ACM
26
Aquilo Capital Management
California
$28.4M +$313K +5,700 +1%
Norges Bank
27
Norges Bank
Norway
$27.1M +$9.92M +180,697 +92%
Adage Capital Partners
28
Adage Capital Partners
Massachusetts
$26.2M -$1.92M -35,000 -9%
Millennium Management
29
Millennium Management
New York
$25.5M +$12.8M +233,895 +192%
MWNA
30
Marshall Wace North America
New York
$25.1M +$7.24M +131,861 +61%
Holocene Advisors
31
Holocene Advisors
New York
$25M +$7.02M +127,857 +58%
SIG
32
Senator Investment Group
New York
$23.3M +$17.8M +325,000 New
CTA
33
Carillon Tower Advisers
Florida
$22.6M – – –
Susquehanna International Group
34
Susquehanna International Group
Pennsylvania
$21.9M +$16.8M +305,127 New
CA
35
Corriente Advisors
Texas
$18.1M +$13.9M +252,500 New
Artisan Partners
36
Artisan Partners
Wisconsin
$17.6M +$13.5M +244,994 New
PM
37
Prosight Management
Texas
$17M -$5.02M -91,478 -28%
OM
38
Opaleye Management
Massachusetts
$15M +$275K +5,000 +2%
FCM
39
Farallon Capital Management
California
$14.3M +$5.44M +99,078 +98%
SM
40
Senvest Management
New York
$14.3M +$4.05M +73,784 +59%
Two Sigma Advisers
41
Two Sigma Advisers
New York
$13M -$439K -8,000 -4%
VC
42
Voss Capital
Texas
$12.9M +$9.91M +180,497 New
RI
43
RTW Investments
New York
$10.9M +$395K +7,187 +5%
SPC
44
Slate Path Capital
New York
$10M +$7.69M +140,000 New
SFM
45
Sphera Funds Management
Israel
$10M -$2.09M -37,986 -21%
LGM
46
Logos Global Management
California
$9.92M +$7.6M +138,425 New
Vanguard Group
47
Vanguard Group
Pennsylvania
$9.01M +$549K +9,994 +9%
BCM
48
Bluefin Capital Management
New York
$8.9M +$3.92M +71,409 +135%
California Public Employees Retirement System
49
California Public Employees Retirement System
California
$8.22M +$1.85M +33,646 +42%
HJIM
50
Henry James International Management
New York
$7.54M -$448K -8,160 -7%
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