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uniQure
QURE

224 hedge funds and large institutions have $1.48B invested in uniQure in 2025 Q4 according to their latest regulatory filings, with 72 funds opening new positions, 72 increasing their positions, 61 reducing their positions, and 63 closing their positions.

New
Increased
Maintained
Reduced
Closed

260% more call options, than puts

Call options by funds: $228M | Put options by funds: $63.5M

18% more repeat investments, than reductions

Existing positions increased: 72 | Existing positions reduced: 61

14% more first-time investments, than exits

New positions opened: 72 | Existing positions closed: 63

3% more funds holding

Funds holding: 218 → 224 (+6)

1.58% less ownership

Funds ownership: 100.88% → 99.3% (-1.6%)

54% less capital invested

Capital invested by funds: $3.23B → $1.48B (-$1.75B)

80% less funds holding in top 10

Funds holding in top 10: 15 → 3 (-12)

Holders
224
Holders Change
+6
Holders Change %
+2.75%
% of All Funds
2.72%
Holding in Top 10
3
Holding in Top 10 Change
-12
Holding in Top 10 Change %
-80%
% of All Funds
0.04%
New
72
Increased
72
Reduced
61
Closed
63
Calls
$228M
Puts
$63.5M
Net Calls
+$165M
Net Calls Change
+$155M

Top Buyers

1
State Street
State Street
Massachusetts
+$69M
2
JP Morgan Chase
JP Morgan Chase
New York
+$68.9M
3
ACA
Avoro Capital Advisors
New York
+$65.8M
4
MB
MPM BioImpact
Massachusetts
+$53.3M
5
SCM
Suvretta Capital Management
New York
+$47M

Top Sellers

1
EC
EcoR1 Capital
California
-$233M
2
Franklin Resources
Franklin Resources
California
-$47.9M
3
FAM
Fred Alger Management
New York
-$36.5M
4
EP
Eversept Partners
New York
-$31.4M
5
DTC
Deep Track Capital
Connecticut
-$28.2M
Name Holding Trade Value Shares
Change 		Change in
Stake
OP
201
ORG Partners
Indiana
$2.72K +$4.4K +114 New
EWA
202
EverSource Wealth Advisors
Alabama
$2.61K – – –
TFA
203
Toth Financial Advisory
Virginia
$2.39K -$2.51K -65 -39%
BWA
204
Basecamp Wealth Advisors
Washington
$2.18K +$3.51K +91 New
VCM
205
Versant Capital Management
Arizona
$2.03K -$3.09K -80 -48%
TRCT
206
Tower Research Capital (TRC)
New York
$1.82K -$37.3K -966 -93%
TFA
207
Transamerica Financial Advisors
Florida
$1.7K +$2.74K +71 New
GRP
208
Global Retirement Partners
California
$1.6K -$8.99K -233 -78%
GWM
209
Greenline Wealth Management
Florida
$1.24K +$2.01K +52 New
CIA
210
Cape Investment Advisory
Georgia
$957 +$1.54K +40 New
CFB
211
Cullen/Frost Bankers
Texas
$814 +$1.31K +34 New
MCM
212
MAI Capital Management
Ohio
$671 +$656 +17 +155%
CA
213
CoreCap Advisors
Michigan
$455 +$733 +19 New
WA
214
WPG Advisers
Maryland
$239 -$7.18K -186 -95%
LFG
215
Larson Financial Group
Missouri
$191 – – –
GI
216
GAMMA Investing
California
$191 +$154 +4 +100%
AAP
217
Arax Advisory Partners
Colorado
$144 -$2.35K -61 -91%
MA
218
Montag & Associates
Georgia
$118 +$193 +5 New
FHC
219
First Horizon Corporation
Tennessee
$72 -$14.8K -383 -99%
Northwestern Mutual Wealth Management
220
Northwestern Mutual Wealth Management
Wisconsin
$72 +$116 +3 New
HNB
221
Huntington National Bank
Ohio
$48 – – –
NS
222
NBC Securities
Alabama
$47 +$77 +2 New
CCA
223
Cygnus Capital Advisors
Georgia
$7 +$11.1K +288 New
MI
224
Motiv8 Investments
Florida
$1 +$1.74K +45 New
EC
225
EcoR1 Capital
California
– -$233M -3,988,971 Closed
7 8
9
10 11

QURE Hedge Fund Activity: Q4 2025 in Review

224 of the 8,223 institutional investors tracked by Wall St. Rank reported a position in uniQure (QURE) for Q4 2025, worth a combined $1.48B — down 54% from $3.23B a quarter earlier.

Buyers outnumbered sellers: 72 funds opened new QURE positions and 63 closed out — a net gain of 9 holders — while 72 added to existing stakes and 61 trimmed.

The largest buyer was State Street, adding an estimated $69M. The largest seller was EcoR1 Capital, exiting entirely with an estimated $233M sold.

  • 224 institutional investors held uniQure (QURE) as of Q4 2025, up from 218 in Q3 2025.
  • Funds reported $1.48B of uniQure stock for Q4 2025, down 54% quarter-over-quarter.
  • 72 funds opened new uniQure positions in Q4 2025 and 63 closed out, a net change of +9 holders.
  • The largest uniQure buyer in Q4 2025 was State Street, an estimated $69M added.
  • The largest uniQure seller in Q4 2025 was EcoR1 Capital, an estimated $233M sold.

Based on aggregated 13F filings for Q4 2025.