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uniQure
QURE

224 hedge funds and large institutions have $1.48B invested in uniQure in 2025 Q4 according to their latest regulatory filings, with 72 funds opening new positions, 72 increasing their positions, 61 reducing their positions, and 63 closing their positions.

New
Increased
Maintained
Reduced
Closed

260% more call options, than puts

Call options by funds: $228M | Put options by funds: $63.5M

18% more repeat investments, than reductions

Existing positions increased: 72 | Existing positions reduced: 61

14% more first-time investments, than exits

New positions opened: 72 | Existing positions closed: 63

3% more funds holding

Funds holding: 218 → 224 (+6)

1.58% less ownership

Funds ownership: 100.88% → 99.3% (-1.6%)

54% less capital invested

Capital invested by funds: $3.23B → $1.48B (-$1.75B)

80% less funds holding in top 10

Funds holding in top 10: 15 → 3 (-12)

Holders
224
Holders Change
+6
Holders Change %
+2.75%
% of All Funds
2.72%
Holding in Top 10
3
Holding in Top 10 Change
-12
Holding in Top 10 Change %
-80%
% of All Funds
0.04%
New
72
Increased
72
Reduced
61
Closed
63
Calls
$228M
Puts
$63.5M
Net Calls
+$165M
Net Calls Change
+$155M

Top Buyers

1
State Street
State Street
Massachusetts
+$69M
2
JP Morgan Chase
JP Morgan Chase
New York
+$68.9M
3
ACA
Avoro Capital Advisors
New York
+$65.8M
4
MB
MPM BioImpact
Massachusetts
+$53.3M
5
SCM
Suvretta Capital Management
New York
+$47M

Top Sellers

1
EC
EcoR1 Capital
California
-$233M
2
Franklin Resources
Franklin Resources
California
-$47.9M
3
FAM
Fred Alger Management
New York
-$36.5M
4
EP
Eversept Partners
New York
-$31.4M
5
DTC
Deep Track Capital
Connecticut
-$28.2M
Name Holding Trade Value Shares
Change 		Change in
Stake
DMKJ
176
David M. Knott Jr
$95.7K +$77.2K +2,000 +100%
Ensign Peak Advisors
177
Ensign Peak Advisors
Utah
$87.3K +$25.1K +650 +22%
Mirae Asset Global Investments
178
Mirae Asset Global Investments
South Korea
$72.4K +$35K +906 +43%
FIA
179
FNY Investment Advisers
New York
$49K +$16.4K +426 +26%
IA
180
IFP Advisors
Florida
$47.6K +$76.8K +1,989 New
SAM
181
Smartleaf Asset Management
Massachusetts
$47.6K +$77.2K +2,000 New
GFM
182
GF Fund Management
China
$29.3K +$1.66K +43 +4%
TM
183
Torren Management
California
$28K +$45.1K +1,169 New
CIBC Private Wealth Group
184
CIBC Private Wealth Group
Georgia
$20.3K – – –
PA
185
Parallel Advisors
California
$20.3K +$32.7K +848 New
Comerica Bank
186
Comerica Bank
Texas
$15.2K +$8.88K +230 +57%
Osaic Holdings
187
Osaic Holdings
Arizona
$14K +$18.4K +476 +429%
Jones Financial Companies
188
Jones Financial Companies
Missouri
$10K -$7.37K -191 -31%
SS
189
SBI Securities
Japan
$6.7K -$33.1K -858 -75%
Carson Wealth (CWM LLC)
190
Carson Wealth (CWM LLC)
Nebraska
$6K – – –
SPIA
191
Steward Partners Investment Advisory
New York
$5.98K – – –
S
192
SignatureFD
Georgia
$5.96K – – –
Rockefeller Capital Management
193
Rockefeller Capital Management
New York
$5.91K -$29.1K -753 -75%
UB
194
UMB Bank
Missouri
$4.79K – – –
EF
195
Entrust Financial
Pennsylvania
$4.55K +$7.33K +190 New
QCG
196
Quadrant Capital Group
Ohio
$4.47K – – –
AF
197
Allworth Financial
California
$4.16K – – –
Daiwa Securities Group
198
Daiwa Securities Group
Japan
$4K – – –
SOW
199
State of Wyoming
Wyoming
$3.85K +$6.21K +161 New
FFA
200
Farther Finance Advisors
California
$2.73K +$4.4K +114 New
6 7
8
9 10

QURE Hedge Fund Activity: Q4 2025 in Review

224 of the 8,223 institutional investors tracked by Wall St. Rank reported a position in uniQure (QURE) for Q4 2025, worth a combined $1.48B — down 54% from $3.23B a quarter earlier.

Buyers outnumbered sellers: 72 funds opened new QURE positions and 63 closed out — a net gain of 9 holders — while 72 added to existing stakes and 61 trimmed.

The largest buyer was State Street, adding an estimated $69M. The largest seller was EcoR1 Capital, exiting entirely with an estimated $233M sold.

  • 224 institutional investors held uniQure (QURE) as of Q4 2025, up from 218 in Q3 2025.
  • Funds reported $1.48B of uniQure stock for Q4 2025, down 54% quarter-over-quarter.
  • 72 funds opened new uniQure positions in Q4 2025 and 63 closed out, a net change of +9 holders.
  • The largest uniQure buyer in Q4 2025 was State Street, an estimated $69M added.
  • The largest uniQure seller in Q4 2025 was EcoR1 Capital, an estimated $233M sold.

Based on aggregated 13F filings for Q4 2025.