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uniQure
QURE

224 hedge funds and large institutions have $1.48B invested in uniQure in 2025 Q4 according to their latest regulatory filings, with 72 funds opening new positions, 72 increasing their positions, 61 reducing their positions, and 63 closing their positions.

New
Increased
Maintained
Reduced
Closed

260% more call options, than puts

Call options by funds: $228M | Put options by funds: $63.5M

18% more repeat investments, than reductions

Existing positions increased: 72 | Existing positions reduced: 61

14% more first-time investments, than exits

New positions opened: 72 | Existing positions closed: 63

3% more funds holding

Funds holding: 218 → 224 (+6)

1.58% less ownership

Funds ownership: 100.88% → 99.3% (-1.6%)

54% less capital invested

Capital invested by funds: $3.23B → $1.48B (-$1.75B)

80% less funds holding in top 10

Funds holding in top 10: 15 → 3 (-12)

Holders
224
Holders Change
+6
Holders Change %
+2.75%
% of All Funds
2.72%
Holding in Top 10
3
Holding in Top 10 Change
-12
Holding in Top 10 Change %
-80%
% of All Funds
0.04%
New
72
Increased
72
Reduced
61
Closed
63
Calls
$228M
Puts
$63.5M
Net Calls
+$165M
Net Calls Change
+$155M

Top Buyers

1
State Street
State Street
Massachusetts
+$69M
2
JP Morgan Chase
JP Morgan Chase
New York
+$68.9M
3
ACA
Avoro Capital Advisors
New York
+$65.8M
4
MB
MPM BioImpact
Massachusetts
+$53.3M
5
SCM
Suvretta Capital Management
New York
+$47M

Top Sellers

1
EC
EcoR1 Capital
California
-$233M
2
Franklin Resources
Franklin Resources
California
-$47.9M
3
FAM
Fred Alger Management
New York
-$36.5M
4
EP
Eversept Partners
New York
-$31.4M
5
DTC
Deep Track Capital
Connecticut
-$28.2M
Name Holding Trade Value Shares
Change 		Change in
Stake
TD Asset Management
126
TD Asset Management
Ontario, Canada
$568K -$2.76M -71,410 -75%
Russell Investments Group
127
Russell Investments Group
United Kingdom
$567K -$4.87M -126,144 -84%
LPL Financial
128
LPL Financial
California
$526K -$932K -24,145 -52%
Marshall Wace
129
Marshall Wace
United Kingdom
$506K -$3.36M -87,051 -80%
JGC
130
J. Goldman & Co
New York
$485K +$781K +20,250 New
VCM
131
Voleon Capital Management
California
$484K +$781K +20,243 New
BGM
132
Burkehill Global Management
New York
$479K – – –
State of Wisconsin Investment Board
133
State of Wisconsin Investment Board
Wisconsin
$464K +$611K +15,822 +443%
Zurich Cantonal Bank
134
Zurich Cantonal Bank
Switzerland
$455K -$34.3K -890 -4%
AssetMark Inc
135
AssetMark Inc
California
$445K +$718K +18,613 New
CHAM
136
Clear Harbor Asset Management
Connecticut
$404K +$382K +9,900 +141%
Janus Henderson Group
137
Janus Henderson Group
United Kingdom
$404K -$116K -3,000 -15%
Manulife (Manufacturers Life Insurance)
138
Manulife (Manufacturers Life Insurance)
Ontario, Canada
$391K -$1.25M -32,300 -66%
QCM
139
Qsemble Capital Management
New York
$381K +$615K +15,931 New
PCM
140
Prelude Capital Management
New York
$377K +$138K +3,579 +29%
Nomura Holdings
141
Nomura Holdings
Japan
$373K +$601K +15,584 New
Handelsbanken Fonder
142
Handelsbanken Fonder
Sweden
$357K +$575K +14,900 New
LPC
143
Lion Point Capital
New York
$352K +$567K +14,700 New
FCM
144
Farallon Capital Management
California
$335K -$21.3M -551,000 -98%
SEI Investments
145
SEI Investments
Pennsylvania
$333K -$2.06M -53,335 -79%
VIA
146
Virtus Investment Advisers
Connecticut
$326K +$252K +6,520 +92%
Lido Advisors
147
Lido Advisors
California
$324K – – –
FC
148
FORA Capital
Florida
$319K +$514K +13,313 New
FGP
149
Freestone Grove Partners
California
$311K +$501K +12,984 New
LIP
150
Lighthouse Investment Partners
Florida
$299K +$482K +12,500 New
4 5
6
7 8

QURE Hedge Fund Activity: Q4 2025 in Review

224 of the 8,223 institutional investors tracked by Wall St. Rank reported a position in uniQure (QURE) for Q4 2025, worth a combined $1.48B — down 54% from $3.23B a quarter earlier.

Buyers outnumbered sellers: 72 funds opened new QURE positions and 63 closed out — a net gain of 9 holders — while 72 added to existing stakes and 61 trimmed.

The largest buyer was State Street, adding an estimated $69M. The largest seller was EcoR1 Capital, exiting entirely with an estimated $233M sold.

  • 224 institutional investors held uniQure (QURE) as of Q4 2025, up from 218 in Q3 2025.
  • Funds reported $1.48B of uniQure stock for Q4 2025, down 54% quarter-over-quarter.
  • 72 funds opened new uniQure positions in Q4 2025 and 63 closed out, a net change of +9 holders.
  • The largest uniQure buyer in Q4 2025 was State Street, an estimated $69M added.
  • The largest uniQure seller in Q4 2025 was EcoR1 Capital, an estimated $233M sold.

Based on aggregated 13F filings for Q4 2025.