uniQure
QURE
224 hedge funds and large institutions have $1.48B invested in uniQure in 2025 Q4 according to their latest regulatory filings, with 72 funds opening new positions, 72 increasing their positions, 61 reducing their positions, and 63 closing their positions.
260% more call options, than puts
Call options by funds: $228M | Put options by funds: $63.5M
18% more repeat investments, than reductions
Existing positions increased: 72 | Existing positions reduced: 61
14% more first-time investments, than exits
New positions opened: 72 | Existing positions closed: 63
3% more funds holding
Funds holding: 218 → 224 (+6)
1.58% less ownership
Funds ownership: 100.88% → 99.3% (-1.6%)
54% less capital invested
Capital invested by funds: $3.23B → $1.48B (-$1.75B)
80% less funds holding in top 10
Funds holding in top 10: 15 → 3 (-12)
Top Buyers
| 1 |
State Street
Boston,
Massachusetts
|
+$69M |
| 2 |
JP Morgan Chase
New York
|
+$68.9M |
| 3 |
ACA
Avoro Capital Advisors
New York
|
+$65.8M |
| 4 |
MB
MPM BioImpact
Boston,
Massachusetts
|
+$53.3M |
| 5 |
SCM
Suvretta Capital Management
New York
|
+$47M |
Top Sellers
| 1 |
EC
EcoR1 Capital
San Francisco,
California
|
-$233M |
| 2 |
Franklin Resources
San Mateo,
California
|
-$47.9M |
| 3 |
FAM
Fred Alger Management
New York
|
-$36.5M |
| 4 |
EP
Eversept Partners
New York
|
-$31.4M |
| 5 |
DTC
Deep Track Capital
Greenwich,
Connecticut
|
-$28.2M |
| Name | Holding | Trade Value |
Shares Change |
Change in Stake |
|
|---|---|---|---|---|---|
276
Commonwealth Equity Services
Waltham,
Massachusetts
| – | -$226K | -3,880 | Closed |
|
277
Westfield Capital Management
Boston,
Massachusetts
| – | -$223K | -3,828 | Closed |
|
278
T. Rowe Price Investment Management
Baltimore,
Maryland
| – | -$58K | -977 | Closed |
|
|
PTC
279
Private Trust Company
Cleveland,
Ohio
| – | -$28.3K | -485 | Closed |
|
|
SIC
280
Salem Investment Counselors
Winston Salem,
North Carolina
| – | -$17.5K | -300 | Closed |
|
|
WTA
281
Washington Trust Advisors
Wellesley,
Massachusetts
| – | -$7.06K | -121 | Closed |
|
|
CIAM
282
Caitong International Asset Management
Hong Kong
| – | -$6.77K | -116 | Closed |
|
|
LI
283
LRI Investments
Palm Beach Gardens,
Florida
| – | -$5.11K | -87 | Closed |
|
|
GBT
284
Grove Bank & Trust
Miami,
Florida
| – | -$4.09K | -70 | Closed |
|
|
AA
285
Ancora Advisors
Cleveland,
Ohio
| – | -$2.98K | -51 | Closed |
|
|
BAM
286
Bellevue Asset Management
Bellevue,
Washington
| – | -$2.69K | -46 | Closed |
|
|
PS
287
Principal Securities
Des Moines,
Iowa
| – | -$1.11K | -19 | Closed |
|
QURE Hedge Fund Activity: Q4 2025 in Review
224 of the 8,223 institutional investors tracked by Wall St. Rank reported a position in uniQure (QURE) for Q4 2025, worth a combined $1.48B — down 54% from $3.23B a quarter earlier.
Buyers outnumbered sellers: 72 funds opened new QURE positions and 63 closed out — a net gain of 9 holders — while 72 added to existing stakes and 61 trimmed.
The largest buyer was State Street, adding an estimated $69M. The largest seller was EcoR1 Capital, exiting entirely with an estimated $233M sold.
- 224 institutional investors held uniQure (QURE) as of Q4 2025, up from 218 in Q3 2025.
- Funds reported $1.48B of uniQure stock for Q4 2025, down 54% quarter-over-quarter.
- 72 funds opened new uniQure positions in Q4 2025 and 63 closed out, a net change of +9 holders.
- The largest uniQure buyer in Q4 2025 was State Street, an estimated $69M added.
- The largest uniQure seller in Q4 2025 was EcoR1 Capital, an estimated $233M sold.
Based on aggregated 13F filings for Q4 2025.