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uniQure
QURE

224 hedge funds and large institutions have $1.48B invested in uniQure in 2025 Q4 according to their latest regulatory filings, with 72 funds opening new positions, 72 increasing their positions, 61 reducing their positions, and 63 closing their positions.

New
Increased
Maintained
Reduced
Closed

260% more call options, than puts

Call options by funds: $228M | Put options by funds: $63.5M

18% more repeat investments, than reductions

Existing positions increased: 72 | Existing positions reduced: 61

14% more first-time investments, than exits

New positions opened: 72 | Existing positions closed: 63

3% more funds holding

Funds holding: 218 → 224 (+6)

1.58% less ownership

Funds ownership: 100.88% → 99.3% (-1.6%)

54% less capital invested

Capital invested by funds: $3.23B → $1.48B (-$1.75B)

80% less funds holding in top 10

Funds holding in top 10: 15 → 3 (-12)

Holders
224
Holders Change
+6
Holders Change %
+2.75%
% of All Funds
2.72%
Holding in Top 10
3
Holding in Top 10 Change
-12
Holding in Top 10 Change %
-80%
% of All Funds
0.04%
New
72
Increased
72
Reduced
61
Closed
63
Calls
$228M
Puts
$63.5M
Net Calls
+$165M
Net Calls Change
+$155M

Top Buyers

1
State Street
State Street
Massachusetts
+$69M
2
JP Morgan Chase
JP Morgan Chase
New York
+$68.9M
3
ACA
Avoro Capital Advisors
New York
+$65.8M
4
MB
MPM BioImpact
Massachusetts
+$53.3M
5
SCM
Suvretta Capital Management
New York
+$47M

Top Sellers

1
EC
EcoR1 Capital
California
-$233M
2
Franklin Resources
Franklin Resources
California
-$47.9M
3
FAM
Fred Alger Management
New York
-$36.5M
4
EP
Eversept Partners
New York
-$31.4M
5
DTC
Deep Track Capital
Connecticut
-$28.2M
Name Holding Trade Value Shares
Change 		Change in
Stake
SFM
251
Sphera Funds Management
Israel
– -$1.45M -24,900 Closed
AC
252
Aristides Capital
Kentucky
– -$1.31M -22,500 Closed
EAM
253
Exome Asset Management
New York
– -$1.29M -22,090 Closed
PWM
254
Palumbo Wealth Management
New York
– -$1.27M -21,778 Closed
PA
255
Perceptive Advisors
New York
– -$1.17M -20,000 Closed
RCAP
256
Resolute Capital Asset Partners
Colorado
– -$1.17M -20,000 Closed
PCM
257
Polymer Capital Management
New York
– -$1.04M -17,835 Closed
ACM
258
Aquatic Capital Management
Illinois
– -$883K -15,125 Closed
Raymond James Financial
259
Raymond James Financial
Florida
– -$858K -14,698 Closed
Corient Private Wealth
260
Corient Private Wealth
Florida
– -$617K -10,562 Closed
Teacher Retirement System of Texas
261
Teacher Retirement System of Texas
Texas
– -$505K -8,646 Closed
SB
262
SIG Brokerage
New York
– -$302K -7,831 Closed
CCIA
263
Campbell & Co Investment Adviser
Maryland
– -$454K -7,771 Closed
TCWM
264
Total Clarity Wealth Management
Illinois
– -$444K -7,608 Closed
NIM
265
NEOS Investment Management
Connecticut
– -$365K -6,250 Closed
TE
266
Tema ETFs
New York
– -$365K -6,250 Closed
SCM
267
SCS Capital Management
Massachusetts
– -$360K -6,164 Closed
Pictet Asset Management
268
Pictet Asset Management
Switzerland
– -$344K -5,900 Closed
BP
269
Ballentine Partners
Massachusetts
– -$301K -5,153 Closed
Financial Engines Advisors
270
Financial Engines Advisors
California
– -$278K -4,767 Closed
Creative Planning
271
Creative Planning
Kansas
– -$276K -4,735 Closed
SPC
272
Sigma Planning Corp
Michigan
– -$263K -4,500 Closed
RCM
273
Requisite Capital Management
Texas
– -$239K -4,092 Closed
CAS
274
Coppell Advisory Solutions
Texas
– -$238K -4,000 Closed
GCS
275
Gordian Capital (Singapore)
Singapore
– -$228K -3,900 Closed
8 9 10
11
12

QURE Hedge Fund Activity: Q4 2025 in Review

224 of the 8,223 institutional investors tracked by Wall St. Rank reported a position in uniQure (QURE) for Q4 2025, worth a combined $1.48B — down 54% from $3.23B a quarter earlier.

Buyers outnumbered sellers: 72 funds opened new QURE positions and 63 closed out — a net gain of 9 holders — while 72 added to existing stakes and 61 trimmed.

The largest buyer was State Street, adding an estimated $69M. The largest seller was EcoR1 Capital, exiting entirely with an estimated $233M sold.

  • 224 institutional investors held uniQure (QURE) as of Q4 2025, up from 218 in Q3 2025.
  • Funds reported $1.48B of uniQure stock for Q4 2025, down 54% quarter-over-quarter.
  • 72 funds opened new uniQure positions in Q4 2025 and 63 closed out, a net change of +9 holders.
  • The largest uniQure buyer in Q4 2025 was State Street, an estimated $69M added.
  • The largest uniQure seller in Q4 2025 was EcoR1 Capital, an estimated $233M sold.

Based on aggregated 13F filings for Q4 2025.