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uniQure
QURE

224 hedge funds and large institutions have $1.48B invested in uniQure in 2025 Q4 according to their latest regulatory filings, with 72 funds opening new positions, 72 increasing their positions, 61 reducing their positions, and 63 closing their positions.

New
Increased
Maintained
Reduced
Closed

260% more call options, than puts

Call options by funds: $228M | Put options by funds: $63.5M

18% more repeat investments, than reductions

Existing positions increased: 72 | Existing positions reduced: 61

14% more first-time investments, than exits

New positions opened: 72 | Existing positions closed: 63

3% more funds holding

Funds holding: 218 → 224 (+6)

1.58% less ownership

Funds ownership: 100.88% → 99.3% (-1.6%)

54% less capital invested

Capital invested by funds: $3.23B → $1.48B (-$1.75B)

80% less funds holding in top 10

Funds holding in top 10: 15 → 3 (-12)

Holders
224
Holders Change
+6
Holders Change %
+2.75%
% of All Funds
2.72%
Holding in Top 10
3
Holding in Top 10 Change
-12
Holding in Top 10 Change %
-80%
% of All Funds
0.04%
New
72
Increased
72
Reduced
61
Closed
63
Calls
$228M
Puts
$63.5M
Net Calls
+$165M
Net Calls Change
+$155M

Top Buyers

1
State Street
State Street
Massachusetts
+$69M
2
JP Morgan Chase
JP Morgan Chase
New York
+$68.9M
3
ACA
Avoro Capital Advisors
New York
+$65.8M
4
MB
MPM BioImpact
Massachusetts
+$53.3M
5
SCM
Suvretta Capital Management
New York
+$47M

Top Sellers

1
EC
EcoR1 Capital
California
-$233M
2
Franklin Resources
Franklin Resources
California
-$47.9M
3
FAM
Fred Alger Management
New York
-$36.5M
4
EP
Eversept Partners
New York
-$31.4M
5
DTC
Deep Track Capital
Connecticut
-$28.2M
Name Holding Trade Value Shares
Change 		Change in
Stake
DTC
226
Deep Track Capital
Connecticut
– -$28.2M -483,092 Closed
DGM
227
Darwin Global Management
Jersey
– -$23.8M -400,000 Closed
SL
228
Siren LLC
Connecticut
– -$16.1M -275,200 Closed
Macquarie Group
229
Macquarie Group
Australia
– -$15.1M -258,211 Closed
VPC
230
Vestal Point Capital
New York
– -$13.1M -225,000 Closed
RCM
231
RA Capital Management
Massachusetts
– -$11.7M -200,000 Closed
SCM
232
Soleus Capital Management
Connecticut
– -$11.7M -200,000 Closed
Lord, Abbett & Co
233
Lord, Abbett & Co
New Jersey
– -$10.3M -176,025 Closed
BCM
234
Boone Capital Management
Georgia
– -$8.6M -147,317 Closed
Group One Trading
235
Group One Trading
Illinois
– -$5.41M -140,227 Closed
WP
236
Woodline Partners
California
– -$7.62M -130,615 Closed
RA
237
Rosalind Advisors
Ontario, Canada
– -$4.82M -125,000 Closed
ACM
238
Atika Capital Management
New York
– -$5.25M -90,000 Closed
SMH
239
Sanders Morris Harris
Texas
– -$5.08M -87,054 Closed
PSC
240
Patient Square Capital
California
– -$4.38M -75,000 Closed
ACA
241
Apis Capital Advisors
New York
– -$3.72M -63,800 Closed
Verition Fund Management
242
Verition Fund Management
Connecticut
– -$3.38M -57,968 Closed
LP
243
Longaeva Partners
Illinois
– -$3.21M -55,000 Closed
OCAM
244
Owl Creek Asset Management
New York
– -$2.88M -49,389 Closed
MIM
245
Monashee Investment Management
Massachusetts
– -$2.33M -40,000 Closed
GGHC
246
Gilder Gagnon Howe & Co
New York
– -$1.99M -34,084 Closed
SCM
247
Superstring Capital Management
New York
– -$1.94M -33,175 Closed
VCIM
248
Velan Capital Investment Management
Georgia
– -$1.87M -32,000 Closed
Invesco
249
Invesco
Georgia
– -$1.77M -30,264 Closed
VF
250
Virtu Financial
New York
– -$1.65M -28,201 Closed
8 9
10
11 12

QURE Hedge Fund Activity: Q4 2025 in Review

224 of the 8,223 institutional investors tracked by Wall St. Rank reported a position in uniQure (QURE) for Q4 2025, worth a combined $1.48B — down 54% from $3.23B a quarter earlier.

Buyers outnumbered sellers: 72 funds opened new QURE positions and 63 closed out — a net gain of 9 holders — while 72 added to existing stakes and 61 trimmed.

The largest buyer was State Street, adding an estimated $69M. The largest seller was EcoR1 Capital, exiting entirely with an estimated $233M sold.

  • 224 institutional investors held uniQure (QURE) as of Q4 2025, up from 218 in Q3 2025.
  • Funds reported $1.48B of uniQure stock for Q4 2025, down 54% quarter-over-quarter.
  • 72 funds opened new uniQure positions in Q4 2025 and 63 closed out, a net change of +9 holders.
  • The largest uniQure buyer in Q4 2025 was State Street, an estimated $69M added.
  • The largest uniQure seller in Q4 2025 was EcoR1 Capital, an estimated $233M sold.

Based on aggregated 13F filings for Q4 2025.