Pyxis Oncology
PYXS
78 hedge funds and large institutions have $40.5M invested in Pyxis Oncology in 2026 Q1 according to their latest regulatory filings, with 14 funds opening new positions, 11 increasing their positions, 36 reducing their positions, and 14 closing their positions.
2,800% more call options, than puts
Call options by funds: $290K | Put options by funds: $10K
100% more funds holding in top 10
Funds holding in top 10: 1 → 2 (+1)
17% more capital invested
Capital invested by funds: $34.7M → $40.5M (+$5.8M)
0% more first-time investments, than exits
New positions opened: 14 | Existing positions closed: 14
1% less funds holding
Funds holding: 79 → 78 (-1)
4.62% less ownership
Funds ownership: 48.5% → 43.88% (-4.6%)
69% less repeat investments, than reductions
Existing positions increased: 11 | Existing positions reduced: 36
Top Buyers
Top Sellers
| 1 |
Bank of America
Charlotte,
North Carolina
|
-$861K |
| 2 |
Jane Street
New York
|
-$726K |
| 3 |
HP
HealthInvest Partners
Stockholm,
Sweden
|
-$633K |
| 4 |
Millennium Management
New York
|
-$521K |
| 5 |
ECM
ExodusPoint Capital Management
New York
|
-$365K |
PYXS Hedge Fund Activity: Q1 2026 in Review
78 of the 8,126 institutional investors tracked by Wall St. Rank reported a position in Pyxis Oncology (PYXS) for Q1 2026, worth a combined $40.5M — up 17% from $34.7M a quarter earlier.
Fund positioning in PYXS was balanced in Q1 2026: 14 funds opened new positions, 14 closed out, 11 added to existing stakes and 36 trimmed.
The largest buyer was Jacobs Levy Equity Management, opening a new position worth an estimated $695K. The largest seller was Bank of America, cutting an estimated $861K.
- 78 institutional investors held Pyxis Oncology (PYXS) as of Q1 2026, down from 79 in Q4 2025.
- Funds reported $40.5M of Pyxis Oncology stock for Q1 2026, up 17% quarter-over-quarter.
- 14 funds opened new Pyxis Oncology positions in Q1 2026 and 14 closed out, a net change of 0 holders.
- The largest Pyxis Oncology buyer in Q1 2026 was Jacobs Levy Equity Management, an estimated $695K added.
- The largest Pyxis Oncology seller in Q1 2026 was Bank of America, an estimated $861K sold.
Based on aggregated 13F filings for Q1 2026.