Two Sigma Investments
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Two Sigma Investments’s Pyxis Oncology PYXS Stock Holding History

Two Sigma Investments’s Portfolio PYXS Stock Details PYXS Fund Activity
Bought
Maintained
Sold
Quarter Market Value Status Shares Change in
Stake 		Trade Value Portfolio Weight Portfolio Position
2026
Q1 		$107K Sell
73,300
-32,228
-31% -$48.6K ﹤0.01% 4381
2025
Q4 		$121K Buy
105,528
+59,027
+127% +$208K ﹤0.01% 3844
2025
Q3 		$103K Buy
+46,501
New +$67K ﹤0.01% 3465
2025
Q1 		– Sell
-17,067
Closed -$26.6K – 3435
2024
Q4 		$26.6K Sell
17,067
-7,515
-31% -$21.7K ﹤0.01% 3088
2024
Q3 		$90.2K Sell
24,582
-71,121
-74% -$249K ﹤0.01% 2912
2024
Q2 		$317K Buy
+95,703
New +$402K ﹤0.01% 2572
2024
Q1 		– Sell
-91,563
Closed -$165K – 3315
2023
Q4 		$165K Sell
91,563
-28,250
-24% -$48.4K ﹤0.01% 2875
2023
Q3 		$238K Buy
119,813
+11,406
+11% +$26.4K ﹤0.01% 2579
2023
Q2 		$278K Buy
+108,407
New +$344K ﹤0.01% 2538
2023
Q1 		– Sell
-35,477
Closed -$47.5K – 3163
2022
Q4 		$47.5K Sell
35,477
-2,200
-6% -$3.3K ﹤0.01% 2597
2022
Q3 		$74K Sell
37,677
-4,619
-11% -$12.1K ﹤0.01% 2270
2022
Q2 		$101K Buy
+42,296
New +$113K ﹤0.01% 2268

Other funds holding PYXS

P
Pfizer New York $239M AUM 232.47% 1-Year Est. Return
LCM
Laurion Capital Management New York $2.29B AUM 75.73% 1-Year Est. Return
GGI
GordonMD Global Investments Beverely Hills, California $144M AUM
VCM
Vanguard Capital Management Malvern, Pennsylvania $4.04T AUM
HP
HealthInvest Partners Stockholm, Sweden $310M AUM 37.86% 1-Year Est. Return
PAI
Palo Alto Investors Palo Alto, California $654M AUM 77.8% 1-Year Est. Return
6CM
683 Capital Management New York $1.92B AUM 85.52% 1-Year Est. Return
Renaissance Technologies
Renaissance Technologies New York $63.9B AUM 45.56% 1-Year Est. Return
BlackRock
BlackRock New York $5.72T AUM 30.48% 1-Year Est. Return
Geode Capital Management
Geode Capital Management Boston, Massachusetts $1.61T AUM 30.72% 1-Year Est. Return

Two Sigma Investments's PYXS Position: Q1 2026 in Review

Two Sigma Investments reduced its Pyxis Oncology (PYXS) stake by 31% in Q1 2026, selling an estimated $48.6K and leaving 73,300 shares worth $107K. The position accounts for ﹤0.01% of the portfolio, ranked #4381.

Two Sigma Investments first reported a position in PYXS in Q2 2022 and has held it in 12 quarters since. The position peaked at $317K in Q2 2024. 78 funds tracked by Wall St. Rank hold PYXS as of Q1 2026.

  • Two Sigma Investments held 73,300 shares of Pyxis Oncology worth $107K as of Q1 2026.
  • Two Sigma Investments sold 32,228 Pyxis Oncology shares in Q1 2026, an estimated $48.6K.
  • Pyxis Oncology made up ﹤0.01% of Two Sigma Investments's portfolio in Q1 2026, its #4381 holding.
  • Two Sigma Investments first reported a position in Pyxis Oncology in Q2 2022 and has held it in 12 quarters since.
  • Two Sigma Investments's Pyxis Oncology position peaked at $317K in Q2 2024.
  • 78 funds tracked by Wall St. Rank held Pyxis Oncology as of Q1 2026.

Based on Two Sigma Investments's 13F filing for Q1 2026, filed 15 May 2026.