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Pyxis Oncology
PYXS

78 hedge funds and large institutions have $40.5M invested in Pyxis Oncology in 2026 Q1 according to their latest regulatory filings, with 14 funds opening new positions, 11 increasing their positions, 36 reducing their positions, and 14 closing their positions.

New
Increased
Maintained
Reduced
Closed

2,800% more call options, than puts

Call options by funds: $290K | Put options by funds: $10K

100% more funds holding in top 10

Funds holding in top 10: 1 → 2 (+1)

17% more capital invested

Capital invested by funds: $34.7M → $40.5M (+$5.8M)

0% more first-time investments, than exits

New positions opened: 14 | Existing positions closed: 14

1% less funds holding

Funds holding: 79 → 78 (-1)

4.62% less ownership

Funds ownership: 48.5% → 43.88% (-4.6%)

69% less repeat investments, than reductions

Existing positions increased: 11 | Existing positions reduced: 36

Holders
78
Holders Change
-1
Holders Change %
-1.27%
% of All Funds
0.96%
Holding in Top 10
2
Holding in Top 10 Change
+1
Holding in Top 10 Change %
+100%
% of All Funds
0.02%
New
14
Increased
11
Reduced
36
Closed
14
Calls
$290K
Puts
$10K
Net Calls
+$280K
Net Calls Change
-$218K

Top Buyers

1
Jacobs Levy Equity Management
Jacobs Levy Equity Management
New Jersey
+$695K
2
LCM
Laurion Capital Management
New York
+$303K
3
Renaissance Technologies
Renaissance Technologies
New York
+$242K
4
Acadian Asset Management
Acadian Asset Management
Massachusetts
+$217K
5
PAM
Panagora Asset Management
Massachusetts
+$105K

Top Sellers

1
Bank of America
Bank of America
North Carolina
-$861K
2
Jane Street
Jane Street
New York
-$726K
3
HP
HealthInvest Partners
Sweden
-$633K
4
Millennium Management
Millennium Management
New York
-$521K
5
ECM
ExodusPoint Capital Management
New York
-$365K
Name Holding Trade Value Shares
Change 		Change in
Stake
Fidelity Investments
51
Fidelity Investments
Massachusetts
$17.4K -$1.43K -946 -7%
PFWA
52
Paces Ferry Wealth Advisors
Georgia
$16.7K – – –
Qube Research & Technologies (QRT)
53
Qube Research & Technologies (QRT)
United Kingdom
$16.5K -$203K -134,527 -92%
CUAMC
54
China Universal Asset Management Company
China
$16.1K +$1.36K +903 +9%
TRCT
55
Tower Research Capital (TRC)
New York
$15.1K -$720 -478 -4%
NA
56
NewEdge Advisors
Louisiana
$15K – – –
PNC Financial Services Group
57
PNC Financial Services Group
Pennsylvania
$9.49K +$9.8K +6,500 New
Royal Bank of Canada
58
Royal Bank of Canada
Ontario, Canada
$9K -$74.9K -49,712 -89%
WCM
59
Winthrop Capital Management
Indiana
$9K – – –
HIMS
60
Hager Investment Management Services
New Hampshire
$7.3K +$7.54K +5,000 New
JP Morgan Chase
61
JP Morgan Chase
New York
$6.57K -$514 -341 -6%
Mirae Asset Global Investments
62
Mirae Asset Global Investments
South Korea
$4.74K +$335 +222 +7%
Federated Hermes
63
Federated Hermes
Pennsylvania
$4.64K +$1.94K +1,287 +68%
Citigroup
64
Citigroup
New York
$2.54K -$1.75K -1,162 -40%
BNP Paribas Financial Markets
65
BNP Paribas Financial Markets
France
$2.42K -$34.1K -22,625 -93%
GFM
66
GF Fund Management
China
$1.92K +$59 +39 +3%
Nisa Investment Advisors
67
Nisa Investment Advisors
Missouri
$1.4K – – –
PWA
68
Physician Wealth Advisors
Utah
$1.38K – – –
Balyasny Asset Management
69
Balyasny Asset Management
Illinois
$1.08K -$11.3K -7,484 -91%
Jones Financial Companies
70
Jones Financial Companies
Missouri
$655 – – –
Wells Fargo
71
Wells Fargo
California
$416 -$3.01K -2,000 -88%
Simplex Trading
72
Simplex Trading
Illinois
$369 -$14.4K -9,537 -97%
CFM
73
Cornerstone Financial Management
Massachusetts
$251 – – –
Carson Wealth (CWM LLC)
74
Carson Wealth (CWM LLC)
Nebraska
$50 -$54 -36 -51%
AAP
75
Arax Advisory Partners
Colorado
$20 -$20 -13 -93%
1 2
3
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PYXS Hedge Fund Activity: Q1 2026 in Review

78 of the 8,126 institutional investors tracked by Wall St. Rank reported a position in Pyxis Oncology (PYXS) for Q1 2026, worth a combined $40.5M — up 17% from $34.7M a quarter earlier.

Fund positioning in PYXS was balanced in Q1 2026: 14 funds opened new positions, 14 closed out, 11 added to existing stakes and 36 trimmed.

The largest buyer was Jacobs Levy Equity Management, opening a new position worth an estimated $695K. The largest seller was Bank of America, cutting an estimated $861K.

  • 78 institutional investors held Pyxis Oncology (PYXS) as of Q1 2026, down from 79 in Q4 2025.
  • Funds reported $40.5M of Pyxis Oncology stock for Q1 2026, up 17% quarter-over-quarter.
  • 14 funds opened new Pyxis Oncology positions in Q1 2026 and 14 closed out, a net change of 0 holders.
  • The largest Pyxis Oncology buyer in Q1 2026 was Jacobs Levy Equity Management, an estimated $695K added.
  • The largest Pyxis Oncology seller in Q1 2026 was Bank of America, an estimated $861K sold.

Based on aggregated 13F filings for Q1 2026.