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Prime Medicine
PRME

Overview Fund Activity

123 hedge funds and large institutions have $120M invested in Prime Medicine in 2025 Q1 according to their latest regulatory filings, with 21 funds opening new positions, 41 increasing their positions, 35 reducing their positions, and 27 closing their positions.

New
Increased
Maintained
Reduced
Closed
Holders
123
Holders Change
-7
Holders Change %
-5.38%
% of All Funds
1.67%
Holding in Top 10
1
Holding in Top 10 Change
–
Holding in Top 10 Change %
–
% of All Funds
0.01%
New
21
Increased
41
Reduced
35
Closed
27
Calls
$120K
Puts
$237K
Net Calls
-$117K
Net Calls Change
+$193K

Top Buyers

1
Renaissance Technologies
Renaissance Technologies
New York
+$891K
2
AQR Capital Management
AQR Capital Management
Connecticut
+$453K
3
T. Rowe Price Investment Management
T. Rowe Price Investment Management
Maryland
+$329K
4
GCP
GSA Capital Partners
United Kingdom
+$275K
5
Susquehanna International Group
Susquehanna International Group
Pennsylvania
+$210K

Top Sellers

1
AIM
ARK Investment Management
Florida
-$4.09M
2
WHG
Westwood Holdings Group
Texas
-$2.58M
3
Walleye Capital
Walleye Capital
New York
-$1.18M
4
Bank of America
Bank of America
North Carolina
-$632K
5
BlackRock
BlackRock
New York
-$435K
Name Holding Trade Value Shares
Change 		Shares
Change %
FHA
101
First Horizon Advisors
Tennessee
$1.85K -$352 -177 -16%
FG
102
Fairman Group
Pennsylvania
$1.46K – – –
RA
103
Rise Advisors
New York
$1.14K +$1.14K +575 New
SS
104
SBI Securities
Japan
$1.14K -$1.26K -631 -52%
Daiwa Securities Group
105
Daiwa Securities Group
Japan
$1K – – –
PWMG
106
Prestige Wealth Management Group
New Jersey
$864 +$864 +434 New
HFS
107
Hughes Financial Services
Virginia
$857 +$857 +480 New
PS
108
Principal Securities
Iowa
$818 – – –
PNC Financial Services Group
109
PNC Financial Services Group
Pennsylvania
$645 +$354 +178 +122%
Comerica Bank
110
Comerica Bank
Texas
$628 -$1.51K -758 -71%
Nisa Investment Advisors
111
Nisa Investment Advisors
Missouri
$627 -$24.5K -12,301 -98%
RIL
112
Rothschild Investment LLC
Illinois
$627 +$70 +35 +13%
CCM
113
Coldstream Capital Management
Washington
$564 +$564 +283 New
LFG
114
Larson Financial Group
Missouri
$398 +$398 +200 New
Osaic Holdings
115
Osaic Holdings
Arizona
$324 -$443 -224 -58%
PA
116
Parallel Advisors
California
$219 +$219 +110 New
SCM
117
Sterling Capital Management
North Carolina
$115 – – –
Russell Investments Group
118
Russell Investments Group
United Kingdom
$103 -$666 -336 -87%
TWD
119
True Wealth Design
Ohio
$100 +$100 +50 New
CI
120
Cordant Inc
Oregon
$66 +$66 +33 New
IA
121
IFP Advisors
Florida
$48 – – –
WHG
122
Westwood Holdings Group
Texas
– -$2.58M -883,129 Closed
Walleye Capital
123
Walleye Capital
New York
– -$1.18M -403,739 Closed
SFI
124
Susquehanna Fundamental Investments
Pennsylvania
– -$423K -144,719 Closed
ECM
125
ExodusPoint Capital Management
New York
– -$385K -131,732 Closed
2 3 4
5
6