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Prime Medicine
PRME

105 hedge funds and large institutions have $433M invested in Prime Medicine in 2023 Q4 according to their latest regulatory filings, with 34 funds opening new positions, 26 increasing their positions, 27 reducing their positions, and 12 closing their positions.

New
Increased
Maintained
Reduced
Closed

183% more first-time investments, than exits

New positions opened: 34 | Existing positions closed: 12

27% more funds holding

Funds holding: 83 → 105 (+22)

0% more funds holding in top 10

Funds holding in top 10: 2 → 2 (0)

0.64% less ownership

Funds ownership: 50.89% → 50.25% (-0.64%)

4% less repeat investments, than reductions

Existing positions increased: 26 | Existing positions reduced: 27

8% less capital invested

Capital invested by funds: $472M → $433M (-$39M)

33% less call options, than puts

Call options by funds: $375K | Put options by funds: $558K

Holders
105
Holders Change
+22
Holders Change %
+26.51%
% of All Funds
1.53%
Holding in Top 10
2
Holding in Top 10 Change
–
Holding in Top 10 Change %
–
% of All Funds
0.03%
New
34
Increased
26
Reduced
27
Closed
12
Calls
$375K
Puts
$558K
Net Calls
-$183K
Net Calls Change
-$270K

Top Buyers

Rank Fund Capital Flow
1
AIM
ARK Investment Management
Florida
+$3.97M
2
BlackRock
BlackRock
New York
+$3.42M
3
Morgan Stanley
Morgan Stanley
New York
+$2.93M
4
BG
Bollard Group
Massachusetts
+$2.78M
5
Two Sigma Investments
Two Sigma Investments
New York
+$1.35M

Top Sellers

Rank Fund Capital Flow
1
Fidelity International
Fidelity International
Bermuda
-$12.8M
2
State Street
State Street
Massachusetts
-$7.14M
3
EC
EcoR1 Capital
California
-$5.72M
4
MCM
Moore Capital Management
New York
-$4.26M
5
Rafferty Asset Management
Rafferty Asset Management
New York
-$1.23M
Name Holding Trade Value Shares
Change 		Change in
Stake
VAS
26
Vestmark Advisory Solutions
Massachusetts
$1.28M +$1.11M +144,288 New
Millennium Management
27
Millennium Management
New York
$1.19M +$1.04M +134,544 New
WP
28
Woodline Partners
California
$1.06M +$925K +120,060 New
SPS
29
Susquehanna Portfolio Strategies
Pennsylvania
$1.04M +$900K +116,887 New
Bank of New York Mellon
30
Bank of New York Mellon
New York
$1.01M -$8.81K -1,143 -1%
N
31
Nuveen
North Carolina
$958K +$9.02K +1,171 +1%
TI
32
TrueMark Investments
Illinois
$665K +$578K +75,030 New
SFM
33
Sphera Funds Management
Israel
$655K +$570K +73,980 New
Squarepoint
34
Squarepoint
New York
$634K +$432K +56,033 +362%
Walleye Capital
35
Walleye Capital
New York
$605K +$444K +57,606 +538%
Manulife (Manufacturers Life Insurance)
36
Manulife (Manufacturers Life Insurance)
Ontario, Canada
$572K -$871 -113 -0.2%
HF
37
HRT Financial
New York
$523K +$455K +59,116 New
Jane Street
38
Jane Street
New York
$489K +$425K +55,219 New
Barclays
39
Barclays
United Kingdom
$481K -$84K -10,905 -17%
Renaissance Technologies
40
Renaissance Technologies
New York
$472K +$411K +53,292 New
TD Asset Management
41
TD Asset Management
Ontario, Canada
$467K -$399K -51,800 -50%
Goldman Sachs
42
Goldman Sachs
New York
$453K -$59.8K -7,762 -13%
RhumbLine Advisers
43
RhumbLine Advisers
Massachusetts
$451K -$778 -101 -0.2%
Bank of Montreal
44
Bank of Montreal
Ontario, Canada
$430K +$347K +45,000 New
Susquehanna International Group
45
Susquehanna International Group
Pennsylvania
$413K +$359K +46,585 New
Two Sigma Advisers
46
Two Sigma Advisers
New York
$408K +$354K +46,000 New
JP Morgan Chase
47
JP Morgan Chase
New York
$403K +$143K +18,505 +69%
RA
48
Royce & Associates
New York
$353K +$307K +39,837 New
AllianceBernstein
49
AllianceBernstein
Tennessee
$331K +$42.5K +5,520 +17%
EC
50
EntryPoint Capital
New York
$312K +$271K +35,235 New
1
2
3 4 5

PRME Hedge Fund Activity: Q4 2023 in Review

105 of the 6,859 institutional investors tracked by Wall St. Rank reported a position in Prime Medicine (PRME) for Q4 2023, worth a combined $433M — down 8.3% from $472M a quarter earlier.

Buyers outnumbered sellers: 34 funds opened new PRME positions and 12 closed out — a net gain of 22 holders — while 26 added to existing stakes and 27 trimmed.

The largest buyer was ARK Investment Management, adding an estimated $3.97M. The largest seller was Fidelity International, cutting an estimated $12.8M.

  • 105 institutional investors held Prime Medicine (PRME) as of Q4 2023, up from 83 in Q3 2023.
  • Funds reported $433M of Prime Medicine stock for Q4 2023, down 8.3% quarter-over-quarter.
  • 34 funds opened new Prime Medicine positions in Q4 2023 and 12 closed out, a net change of +22 holders.
  • The largest Prime Medicine buyer in Q4 2023 was ARK Investment Management, an estimated $3.97M added.
  • The largest Prime Medicine seller in Q4 2023 was Fidelity International, an estimated $12.8M sold.

Based on aggregated 13F filings for Q4 2023.