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Opko Health
OPK

222 hedge funds and large institutions have $270M invested in Opko Health in 2025 Q2 according to their latest regulatory filings, with 17 funds opening new positions, 56 increasing their positions, 66 reducing their positions, and 48 closing their positions.

New
Increased
Maintained
Reduced
Closed

562% more call options, than puts

Call options by funds: $3.77M | Put options by funds: $569K

10.18% less ownership

Funds ownership: 36.05% → 25.87% (-10%)

13% less funds holding

Funds holding: 255 → 222 (-33)

15% less repeat investments, than reductions

Existing positions increased: 56 | Existing positions reduced: 66

33% less capital invested

Capital invested by funds: $401M → $270M (-$131M)

65% less first-time investments, than exits

New positions opened: 17 | Existing positions closed: 48

Holders
222
Holders Change
-33
Holders Change %
-12.94%
% of All Funds
2.92%
Holding in Top 10
–
Holding in Top 10 Change
–
Holding in Top 10 Change %
–
% of All Funds
–
New
17
Increased
56
Reduced
66
Closed
48
Calls
$3.77M
Puts
$569K
Net Calls
+$3.2M
Net Calls Change
-$1.06M

Top Buyers

Rank Fund Capital Flow
1
Vanguard Group
Vanguard Group
Pennsylvania
+$11.9M
2
BlackRock
BlackRock
New York
+$5.26M
3
UBS Group
UBS Group
Switzerland
+$4.51M
4
Geode Capital Management
Geode Capital Management
Massachusetts
+$2.73M
5
WCM
Whitefort Capital Management
New York
+$2.43M

Top Sellers

Rank Fund Capital Flow
1
SC
Sculptor Capital
New York
-$21.1M
2
DM
Deerfield Management
New York
-$11.5M
3
WAM
Weiss Asset Management
Massachusetts
-$8.8M
4
D.E. Shaw & Co
D.E. Shaw & Co
New York
-$7.85M
5
Millennium Management
Millennium Management
New York
-$7.78M

OPK Hedge Fund Activity: Q2 2025 in Review

222 of the 7,613 institutional investors tracked by Wall St. Rank reported a position in Opko Health (OPK) for Q2 2025, worth a combined $270M — down 33% from $401M a quarter earlier.

Sellers outnumbered buyers: 48 funds closed out of OPK and 17 opened new positions — a net loss of 31 holders — while 66 trimmed existing stakes and 56 added.

The largest buyer was Vanguard Group, adding an estimated $11.9M. The largest seller was Sculptor Capital, exiting entirely with an estimated $21.1M sold.

  • 222 institutional investors held Opko Health (OPK) as of Q2 2025, down from 255 in Q1 2025.
  • Funds reported $270M of Opko Health stock for Q2 2025, down 33% quarter-over-quarter.
  • 17 funds opened new Opko Health positions in Q2 2025 and 48 closed out, a net change of -31 holders.
  • The largest Opko Health buyer in Q2 2025 was Vanguard Group, an estimated $11.9M added.
  • The largest Opko Health seller in Q2 2025 was Sculptor Capital, an estimated $21.1M sold.

Based on aggregated 13F filings for Q2 2025.