Opko Health
220 hedge funds and large institutions have $251M invested in Opko Health in 2025 Q4 according to their latest regulatory filings, with 30 funds opening new positions, 43 increasing their positions, 77 reducing their positions, and 34 closing their positions.
2,006% more call options, than puts
Call options by funds: $2.11M | Put options by funds: $100K
1.26% more ownership
Funds ownership: 24.73% → 25.99% (+1.3%)
6% less funds holding
Funds holding: 233 → 220 (-13)
12% less first-time investments, than exits
New positions opened: 30 | Existing positions closed: 34
17% less capital invested
Capital invested by funds: $304M → $251M (-$52.6M)
44% less repeat investments, than reductions
Existing positions increased: 43 | Existing positions reduced: 77
Top Buyers
| Rank | Fund | Capital Flow |
|---|---|---|
| 1 |
Goldman Sachs
New York
|
+$5.01M |
| 2 |
Citadel Advisors
Miami,
Florida
|
+$3.59M |
| 3 |
BlackRock
New York
|
+$2.34M |
| 4 |
Jane Street
New York
|
+$2.1M |
| 5 |
CA
Clearstead Advisors
Cleveland,
Ohio
|
+$1.23M |
Top Sellers
| Rank | Fund | Capital Flow |
|---|---|---|
| 1 |
Vanguard Group
Malvern,
Pennsylvania
|
-$7.07M |
| 2 |
WAM
Weiss Asset Management
Boston,
Massachusetts
|
-$1.75M |
| 3 |
AQR Capital Management
Greenwich,
Connecticut
|
-$1.18M |
| 4 |
Bank of America
Charlotte,
North Carolina
|
-$968K |
| 5 |
WCM
Whitefort Capital Management
New York
|
-$900K |
OPK Hedge Fund Activity: Q4 2025 in Review
220 of the 8,263 institutional investors tracked by Wall St. Rank reported a position in Opko Health (OPK) for Q4 2025, worth a combined $251M — down 17% from $304M a quarter earlier.
Sellers outnumbered buyers: 34 funds closed out of OPK and 30 opened new positions — a net loss of 4 holders — while 77 trimmed existing stakes and 43 added.
The largest buyer was Goldman Sachs, adding an estimated $5.01M. The largest seller was Vanguard Group, cutting an estimated $7.07M.
- 220 institutional investors held Opko Health (OPK) as of Q4 2025, down from 233 in Q3 2025.
- Funds reported $251M of Opko Health stock for Q4 2025, down 17% quarter-over-quarter.
- 30 funds opened new Opko Health positions in Q4 2025 and 34 closed out, a net change of -4 holders.
- The largest Opko Health buyer in Q4 2025 was Goldman Sachs, an estimated $5.01M added.
- The largest Opko Health seller in Q4 2025 was Vanguard Group, an estimated $7.07M sold.
Based on aggregated 13F filings for Q4 2025.