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Opko Health

255 hedge funds and large institutions have $401M invested in Opko Health in 2025 Q1 according to their latest regulatory filings, with 43 funds opening new positions, 76 increasing their positions, 58 reducing their positions, and 23 closing their positions.

New
Increased
Maintained
Reduced
Closed

490% more call options, than puts

Call options by funds: $5.13M | Put options by funds: $870K

87% more first-time investments, than exits

New positions opened: 43 | Existing positions closed: 23

38% more capital invested

Capital invested by funds: $290M → $401M (+$111M)

31% more repeat investments, than reductions

Existing positions increased: 76 | Existing positions reduced: 58

9% more funds holding

Funds holding: 235255 (+20)

7.1% more ownership

Funds ownership: 28.95%36.05% (+7.1%)

Holders
255
Holders Change
+20
Holders Change %
+8.51%
% of All Funds
3.42%
Holding in Top 10
Holding in Top 10 Change
Holding in Top 10 Change %
% of All Funds
New
43
Increased
76
Reduced
58
Closed
23
Calls
$5.13M
Puts
$870K
Net Calls
+$4.26M
Net Calls Change
+$12.2M
Name Holding Trade Value Shares
Change
Change in
Stake
RCMNY
1
Rubric Capital Management (New York)
New York
$80.9M
Vanguard Group
2
Vanguard Group
Pennsylvania
$49M +$484K +293,740 +1%
BlackRock
3
BlackRock
New York
$45.8M -$928K -563,638 -2%
SC
4
Sculptor Capital
New York
$21.1M +$20.9M +12,717,400 New
WAM
5
Weiss Asset Management
Massachusetts
$18.6M +$18.4M +11,192,800 New
Geode Capital Management
6
Geode Capital Management
Massachusetts
$14M +$71.8K +43,622 +0.5%
State Street
7
State Street
Massachusetts
$13.5M -$1.54M -935,402 -10%
DM
8
Deerfield Management
New York
$11.5M +$11.4M +6,906,362 New
Millennium Management
9
Millennium Management
New York
$10.6M +$2.96M +1,798,385 +39%
Marshall Wace
10
Marshall Wace
United Kingdom
$8.13M +$6.55M +3,974,941 +431%
D.E. Shaw & Co
11
D.E. Shaw & Co
New York
$7.85M +$7.79M +4,731,688 New
Bank of America
12
Bank of America
North Carolina
$6.9M +$5.89M +3,577,300 +615%
Morgan Stanley
13
Morgan Stanley
New York
$6.82M +$1.55M +940,546 +30%
Goldman Sachs
14
Goldman Sachs
New York
$6.64M +$266K +161,394 +4%
Lazard Asset Management
15
Lazard Asset Management
New York
$5.99M +$1.75M +1,060,647 +42%
Northern Trust
16
Northern Trust
Illinois
$5.86M -$277K -168,382 -5%
Charles Schwab
17
Charles Schwab
California
$4.55M -$1.24M -755,420 -22%
JP Morgan Chase
18
JP Morgan Chase
New York
$4.15M +$1.53M +926,361 +59%
UBS Group
19
UBS Group
Switzerland
$4.01M -$3.96M -2,405,794 -50%
Dimensional Fund Advisors
20
Dimensional Fund Advisors
Texas
$3.69M -$76K -46,154 -2%
Citadel Advisors
21
Citadel Advisors
Florida
$3.08M -$2.23M -1,353,764 -42%
AIC
22
AWM Investment Company
New York
$3.07M +$906K +550,000 +42%
GCM
23
Graham Capital Management
Connecticut
$3.01M +$2.98M +1,810,392 New
YDMI
24
Y.D. More Investments
Israel
$2.97M +$621K +377,179 +27%
Two Sigma Investments
25
Two Sigma Investments
New York
$2.73M -$2.95K -1,792 -0.1%

OPK Hedge Fund Activity: Q1 2025 in Review

255 of the 7,458 institutional investors tracked by Wall St. Rank reported a position in Opko Health (OPK) for Q1 2025, worth a combined $401M — up 38% from $290M a quarter earlier.

Buyers outnumbered sellers: 43 funds opened new OPK positions and 23 closed out — a net gain of 20 holders — while 76 added to existing stakes and 58 trimmed.

The largest buyer was Sculptor Capital, opening a new position worth an estimated $20.9M. The largest seller was UBS Group, cutting an estimated $3.96M.

  • 255 institutional investors held Opko Health (OPK) as of Q1 2025, up from 235 in Q4 2024.
  • Funds reported $401M of Opko Health stock for Q1 2025, up 38% quarter-over-quarter.
  • 43 funds opened new Opko Health positions in Q1 2025 and 23 closed out, a net change of +20 holders.
  • The largest Opko Health buyer in Q1 2025 was Sculptor Capital, an estimated $20.9M added.
  • The largest Opko Health seller in Q1 2025 was UBS Group, an estimated $3.96M sold.

Based on aggregated 13F filings for Q1 2025.