D.E. Shaw & Co
OPK icon

D.E. Shaw & Co’s Opko Health OPK Stock Holding History

D.E. Shaw & Co’s Portfolio OPK Stock Details OPK Fund Activity
Bought
Maintained
Sold
Quarter Market Value Status Shares Change in
Stake 		Trade Value Portfolio Weight Portfolio Position
2025
Q2 		– Sell
-4,731,688
Closed -$7.85M – 4613
2025
Q1 		$7.85M Buy
+4,731,688
New +$7.79M 0.01% 1570
2024
Q2 		– Sell
-2,646,084
Closed -$3.18M – 4758
2024
Q1 		$3.18M Sell
2,646,084
-3,196,453
-55% -$3.2M ﹤0.01% 2261
2023
Q4 		$8.82M Sell
5,842,537
-320,902
-5% -$464K 0.01% 1463
2023
Q3 		$9.86M Buy
6,163,439
+460,014
+8% +$838K 0.01% 1294
2023
Q2 		$12.4M Buy
5,703,425
+431,454
+8% +$675K 0.01% 1175
2023
Q1 		$7.7M Sell
5,271,971
-514,206
-9% -$662K 0.01% 1584
2022
Q4 		$7.23M Sell
5,786,177
-182,129
-3% -$287K 0.01% 1742
2022
Q3 		$11.3M Sell
5,968,306
-397,910
-6% -$941K 0.01% 1257
2022
Q2 		$16.1M Buy
6,366,216
+990,990
+18% +$2.89M 0.02% 1018
2022
Q1 		$18.5M Buy
5,375,226
+1,294,225
+32% +$4.57M 0.02% 1090
2021
Q4 		$19.6M Buy
4,081,001
+2,003,147
+96% +$8.11M 0.02% 1103
2021
Q3 		$7.58M Sell
2,077,854
-478,728
-19% -$1.78M 0.01% 1727
2021
Q2 		$10.4M Sell
2,556,582
-979,049
-28% -$3.84M 0.01% 1469
2021
Q1 		$15.2M Buy
3,535,631
+3,505,182
+11,512% +$16.7M 0.01% 1102
2020
Q4 		$120K Sell
30,449
-500,490
-94% -$2.09M ﹤0.01% 3799
2020
Q3 		$1.96M Sell
530,939
-690,879
-57% -$2.92M ﹤0.01% 2423
2020
Q2 		$4.17M Buy
+1,221,818
New +$2.74M 0.01% 1793
2020
Q1 		– Sell
-1,367,150
Closed -$2.01M – 4157
2019
Q4 		$2.01M Sell
1,367,150
-831,068
-38% -$1.39M ﹤0.01% 2470
2019
Q3 		$4.59M Buy
2,198,218
+666,879
+44% +$1.36M 0.01% 1714
2019
Q2 		$3.74M Sell
1,531,339
-185,036
-11% -$404K ﹤0.01% 1804
2019
Q1 		$4.48M Buy
1,716,375
+1,692,210
+7,003% +$5.12M 0.01% 1615
2018
Q4 		$73K Buy
24,165
+4,104
+20% +$13.9K ﹤0.01% 3664
2018
Q3 		$69K Sell
20,061
-421,574
-95% -$2.24M ﹤0.01% 3641
2018
Q2 		$2.08M Buy
441,635
+412,564
+1,419% +$1.56M ﹤0.01% 2205
2018
Q1 		$92K Sell
29,071
-35,719
-55% -$144K ﹤0.01% 3395
2017
Q4 		$317K Sell
64,790
-67,661
-51% -$393K ﹤0.01% 3218
2017
Q3 		$909K Buy
132,451
+71,198
+116% +$449K ﹤0.01% 2544
2017
Q2 		$403K Buy
61,253
+10,903
+22% +$76.4K ﹤0.01% 2905
2017
Q1 		$403K Buy
50,350
+10,179
+25% +$85.7K ﹤0.01% 2834
2016
Q4 		$374K Sell
40,171
-71,453
-64% -$739K ﹤0.01% 3011
2016
Q3 		$1.18M Buy
111,624
+85,393
+326% +$850K ﹤0.01% 2288
2016
Q2 		$245K Buy
26,231
+4,031
+18% +$40.9K ﹤0.01% 3114
2016
Q1 		$231K Sell
22,200
-555,153
-96% -$5.07M ﹤0.01% 3134
2015
Q4 		$5.8M Sell
577,353
-246,145
-30% -$2.47M 0.01% 1303
2015
Q3 		$6.93M Sell
823,498
-609,359
-43% -$8.07M 0.01% 1181
2015
Q2 		$23M Buy
1,432,857
+1,413,655
+7,362% +$22M 0.03% 589
2015
Q1 		$272K Sell
19,202
-966,504
-98% -$12.6M ﹤0.01% 3343
2014
Q4 		$9.85M Buy
985,706
+968,127
+5,507% +$8.29M 0.01% 1122
2014
Q3 		$150K Sell
17,579
-74,832
-81% -$658K ﹤0.01% 3939
2014
Q2 		$817K Buy
92,411
+40,016
+76% +$349K ﹤0.01% 3115
2014
Q1 		$488K Sell
52,395
-267,349
-84% -$2.34M ﹤0.01% 3633
2013
Q4 		$2.7M Buy
+319,744
New +$3.23M ﹤0.01% 2234

Other funds holding OPK

RCMNY
Rubric Capital Management (New York) New York $9.44B AUM 68.42% 1-Year Est. Return
Vanguard Group
Vanguard Group Malvern, Pennsylvania $6.9T AUM 27.45% 1-Year Est. Return
BlackRock
BlackRock New York $5.72T AUM 30.48% 1-Year Est. Return
Geode Capital Management
Geode Capital Management Boston, Massachusetts $1.61T AUM 30.72% 1-Year Est. Return
State Street
State Street Boston, Massachusetts $2.9T AUM 29.55% 1-Year Est. Return
UBS Group
UBS Group Zurich, Switzerland $666B AUM 30.12% 1-Year Est. Return
WAM
Weiss Asset Management Boston, Massachusetts $5.91B AUM 42.42% 1-Year Est. Return
Northern Trust
Northern Trust Chicago, Illinois $757B AUM 28.64% 1-Year Est. Return
Charles Schwab
Charles Schwab San Francisco, California $654B AUM 26.35% 1-Year Est. Return
Marshall Wace
Marshall Wace London, United Kingdom $100B AUM 35.1% 1-Year Est. Return

D.E. Shaw & Co's OPK Position: Q2 2025 in Review

D.E. Shaw & Co sold out of Opko Health (OPK) in Q2 2025, closing a stake of 4,731,688 shares — an estimated $7.85M sold.

D.E. Shaw & Co first reported a position in OPK in Q4 2013 and held it in 42 quarters. The position peaked at $23M in Q2 2015. 222 funds tracked by Wall St. Rank hold OPK as of Q2 2025.

  • D.E. Shaw & Co reported no remaining Opko Health position as of Q2 2025 after selling out during the quarter.
  • D.E. Shaw & Co sold 4,731,688 Opko Health shares in Q2 2025, an estimated $7.85M.
  • D.E. Shaw & Co first reported a position in Opko Health in Q4 2013 and held it in 42 quarters.
  • D.E. Shaw & Co's Opko Health position peaked at $23M in Q2 2015.
  • 222 funds tracked by Wall St. Rank held Opko Health as of Q2 2025.

Based on D.E. Shaw & Co's 13F filing for Q2 2025, filed 14 Aug 2025.