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Opko Health
OPK

255 hedge funds and large institutions have $401M invested in Opko Health in 2025 Q1 according to their latest regulatory filings, with 43 funds opening new positions, 76 increasing their positions, 58 reducing their positions, and 23 closing their positions.

New
Increased
Maintained
Reduced
Closed

490% more call options, than puts

Call options by funds: $5.13M | Put options by funds: $870K

87% more first-time investments, than exits

New positions opened: 43 | Existing positions closed: 23

38% more capital invested

Capital invested by funds: $290M → $401M (+$111M)

31% more repeat investments, than reductions

Existing positions increased: 76 | Existing positions reduced: 58

9% more funds holding

Funds holding: 235 → 255 (+20)

7.1% more ownership

Funds ownership: 28.95% → 36.05% (+7.1%)

Holders
255
Holders Change
+20
Holders Change %
+8.51%
% of All Funds
3.42%
Holding in Top 10
–
Holding in Top 10 Change
–
Holding in Top 10 Change %
–
% of All Funds
–
New
43
Increased
76
Reduced
58
Closed
23
Calls
$5.13M
Puts
$870K
Net Calls
+$4.26M
Net Calls Change
+$12.2M

Top Buyers

Rank Fund Capital Flow
1
SC
Sculptor Capital
New York
+$20.9M
2
WAM
Weiss Asset Management
Massachusetts
+$18.4M
3
DM
Deerfield Management
New York
+$11.4M
4
D.E. Shaw & Co
D.E. Shaw & Co
New York
+$7.79M
5
Marshall Wace
Marshall Wace
United Kingdom
+$6.55M

Top Sellers

Rank Fund Capital Flow
1
UBS Group
UBS Group
Switzerland
-$3.96M
2
Jane Street
Jane Street
New York
-$3.72M
3
Citadel Advisors
Citadel Advisors
Florida
-$2.23M
4
IECM
Intrinsic Edge Capital Management
Illinois
-$1.62M
5
State Street
State Street
Massachusetts
-$1.54M
Name Holding Trade Value Shares
Change 		Change in
Stake
Invesco
26
Invesco
Georgia
$2.7M +$114K +69,111 +4%
AQR Capital Management
27
AQR Capital Management
Connecticut
$2.67M +$2.18M +1,324,988 +467%
AS
28
Altshuler Shaham
Israel
$2.44M +$71.2K +43,202 +3%
N
29
Nuveen
North Carolina
$2.29M -$91.4K -55,523 -4%
GCP
30
GSA Capital Partners
United Kingdom
$2.23M +$431K +261,495 +24%
PI
31
PFG Investments
New York
$2.02M +$93K +56,475 +5%
Bank of New York Mellon
32
Bank of New York Mellon
New York
$1.69M -$7.22K -4,386 -0.4%
Assenagon Asset Management
33
Assenagon Asset Management
Luxembourg
$1.56M +$129K +78,362 +9%
BNP Paribas Financial Markets
34
BNP Paribas Financial Markets
France
$1.48M +$1.38M +839,296 +1,619%
CA
35
Clearstead Advisors
Ohio
$1.47M – – –
HF
36
HRT Financial
New York
$1.46M +$347K +210,604 +31%
TC
37
Tejara Capital
United Kingdom
$1.43M -$602K -365,306 -30%
VOYA Investment Management
38
VOYA Investment Management
Georgia
$1.34M -$733K -445,158 -35%
UBS AM
39
UBS AM
Illinois
$1.3M +$46.5K +28,254 +4%
Susquehanna International Group
40
Susquehanna International Group
Pennsylvania
$1.26M +$1.01M +611,010 +421%
Swiss National Bank
41
Swiss National Bank
Switzerland
$1.1M -$40K -24,300 -4%
Osaic Holdings
42
Osaic Holdings
Arizona
$1.08M +$198K +119,983 +23%
Two Sigma Advisers
43
Two Sigma Advisers
New York
$916K +$281K +170,500 +45%
Jane Street
44
Jane Street
New York
$912K -$3.72M -2,257,583 -80%
AllianceBernstein
45
AllianceBernstein
Tennessee
$837K +$213K +129,070 +34%
T. Rowe Price Associates
46
T. Rowe Price Associates
Maryland
$833K +$76K +46,147 +10%
Norges Bank
47
Norges Bank
Norway
$820K -$1.04M -633,211 -56%
RhumbLine Advisers
48
RhumbLine Advisers
Massachusetts
$814K -$47K -28,544 -6%
Commonwealth Equity Services
49
Commonwealth Equity Services
Massachusetts
$797K +$75.4K +45,795 +11%
XSC
50
X-Square Capital
Puerto Rico
$764K +$492K +298,699 +185%
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OPK Hedge Fund Activity: Q1 2025 in Review

255 of the 7,458 institutional investors tracked by Wall St. Rank reported a position in Opko Health (OPK) for Q1 2025, worth a combined $401M — up 38% from $290M a quarter earlier.

Buyers outnumbered sellers: 43 funds opened new OPK positions and 23 closed out — a net gain of 20 holders — while 76 added to existing stakes and 58 trimmed.

The largest buyer was Sculptor Capital, opening a new position worth an estimated $20.9M. The largest seller was UBS Group, cutting an estimated $3.96M.

  • 255 institutional investors held Opko Health (OPK) as of Q1 2025, up from 235 in Q4 2024.
  • Funds reported $401M of Opko Health stock for Q1 2025, up 38% quarter-over-quarter.
  • 43 funds opened new Opko Health positions in Q1 2025 and 23 closed out, a net change of +20 holders.
  • The largest Opko Health buyer in Q1 2025 was Sculptor Capital, an estimated $20.9M added.
  • The largest Opko Health seller in Q1 2025 was UBS Group, an estimated $3.96M sold.

Based on aggregated 13F filings for Q1 2025.