|
1
|
DekaBank Deutsche Girozentrale
Frankfurt,
Germany
|
$447K
|
–
|
–
|
–
|
|
|
2
|
Hoey Investments
Coatesville,
Pennsylvania
|
$34.1K
|
–
|
–
|
–
|
|
|
3
|
Fidelity Investments
Boston,
Massachusetts
|
–
|
-$256M
|
-7,514,010
|
Closed
|
|
|
4
|
Wellington Management Group
Boston,
Massachusetts
|
–
|
-$198M
|
-5,814,446
|
Closed
|
|
|
5
|
EcoR1 Capital
San Francisco,
California
|
–
|
-$170M
|
-4,982,945
|
Closed
|
|
|
6
|
|
–
|
-$120M
|
-3,527,564
|
Closed
|
|
|
7
|
|
–
|
-$86.1M
|
-2,525,998
|
Closed
|
|
|
8
|
Vanguard Group
Malvern,
Pennsylvania
|
–
|
-$75.5M
|
-2,215,949
|
Closed
|
|
|
9
|
T. Rowe Price Associates
Baltimore,
Maryland
|
–
|
-$75.2M
|
-2,207,187
|
Closed
|
|
|
10
|
Woodline Partners
San Francisco,
California
|
–
|
-$60.8M
|
-1,783,202
|
Closed
|
|
|
11
|
State Street
Boston,
Massachusetts
|
–
|
-$55.8M
|
-1,638,108
|
Closed
|
|
|
12
|
Point72 Asset Management
Stamford,
Connecticut
|
–
|
-$49.8M
|
-1,461,302
|
Closed
|
|
|
13
|
Pictet Asset Management
Carouge,
Switzerland
|
–
|
-$34.7M
|
-1,017,912
|
Closed
|
|
|
14
|
Federated Hermes
Pittsburgh,
Pennsylvania
|
–
|
-$33.9M
|
-995,000
|
Closed
|
|
|
15
|
Geode Capital Management
Boston,
Massachusetts
|
–
|
-$33.1M
|
-969,986
|
Closed
|
|
|
16
|
|
–
|
-$21.6M
|
-633,573
|
Closed
|
|
|
17
|
|
–
|
-$20.9M
|
-612,500
|
Closed
|
|
|
18
|
Silverarc Capital Management
Boston,
Massachusetts
|
–
|
-$16.6M
|
-486,306
|
Closed
|
|
|
19
|
Two Sigma Advisers
New York
|
–
|
-$13.6M
|
-400,600
|
Closed
|
|
|
20
|
Novo Holdings A/S
Hellerup,
Denmark
|
–
|
-$12.8M
|
-375,000
|
Closed
|
|
|
21
|
MPM BioImpact
Boston,
Massachusetts
|
–
|
-$12.6M
|
-369,384
|
Closed
|
|
|
22
|
Northern Trust
Chicago,
Illinois
|
–
|
-$11.6M
|
-339,770
|
Closed
|
|
|
23
|
Charles Schwab
San Francisco,
California
|
–
|
-$11.2M
|
-327,844
|
Closed
|
|
|
24
|
Affinity Asset Advisors
New York
|
–
|
-$8.54M
|
-250,573
|
Closed
|
|
|
25
|
DAFNA Capital Management
Los Angeles,
California
|
–
|
-$7.9M
|
-231,748
|
Closed
|
|
