|
1
|
Fidelity Investments
Boston,
Massachusetts
|
$67.1M
|
+$28.9M
|
+1,721,656
|
+60%
|
|
|
2
|
Omega Fund Management
Boston,
Massachusetts
|
$43.6M
|
–
|
–
|
–
|
|
|
3
|
EcoR1 Capital
San Francisco,
California
|
$41.4M
|
+$11.2M
|
+668,296
|
+31%
|
|
|
4
|
Novo Holdings A/S
Hellerup,
Denmark
|
$38.8M
|
–
|
–
|
–
|
|
|
5
|
|
$26.7M
|
–
|
–
|
–
|
|
|
6
|
|
$9.77M
|
+$6.73M
|
+401,237
|
+152%
|
|
|
7
|
Perceptive Advisors
New York
|
$9.54M
|
–
|
–
|
–
|
|
|
8
|
Fiduciary Trust
Boston,
Massachusetts
|
$3.15M
|
+$3.59M
|
+214,367
|
New
|
|
|
9
|
State Street
Boston,
Massachusetts
|
$2.48M
|
+$1.62M
|
+96,548
|
+133%
|
|
|
10
|
Vanguard Group
Malvern,
Pennsylvania
|
$2.06M
|
+$521K
|
+31,096
|
+28%
|
|
|
11
|
Geode Capital Management
Boston,
Massachusetts
|
$1.75M
|
+$749K
|
+44,666
|
+60%
|
|
|
12
|
Marshall Wace North America
New York
|
$1.12M
|
–
|
–
|
–
|
|
|
13
|
Northern Trust
Chicago,
Illinois
|
$1.12M
|
+$279K
|
+16,635
|
+28%
|
|
|
14
|
Nuveen
Charlotte,
North Carolina
|
$1.12M
|
+$1.28M
|
+76,300
|
New
|
|
|
15
|
Ensign Peak Advisors
Salt Lake City,
Utah
|
$909K
|
-$197K
|
-11,727
|
-16%
|
|
|
16
|
Citadel Advisors
Miami,
Florida
|
$731K
|
+$835K
|
+49,793
|
New
|
|
|
17
|
Sio Capital Management
New York
|
$729K
|
+$833K
|
+49,686
|
New
|
|
|
18
|
Charles Schwab
San Francisco,
California
|
$673K
|
+$214K
|
+12,762
|
+39%
|
|
|
19
|
|
$645K
|
+$737K
|
+43,957
|
New
|
|
|
20
|
DAFNA Capital Management
Los Angeles,
California
|
$543K
|
–
|
–
|
–
|
|
|
21
|
Millennium Management
New York
|
$461K
|
+$526K
|
+31,378
|
New
|
|
|
22
|
Altrinsic Global Advisors
Stamford,
Connecticut
|
$440K
|
+$503K
|
+30,000
|
New
|
|
|
23
|
Bank of New York Mellon
New York
|
$430K
|
+$306K
|
+18,243
|
+165%
|
|
|
24
|
|
$427K
|
+$488K
|
+29,079
|
New
|
|
|
25
|
State of Wisconsin Investment Board
Madison,
Wisconsin
|
$242K
|
+$277K
|
+16,500
|
New
|
|
