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Lexicon Pharmaceuticals
LXRX

136 hedge funds and large institutions have $505M invested in Lexicon Pharmaceuticals in 2026 Q1 according to their latest regulatory filings, with 31 funds opening new positions, 41 increasing their positions, 26 reducing their positions, and 15 closing their positions.

New
Increased
Maintained
Reduced
Closed

1,280% more call options, than puts

Call options by funds: $3.34M | Put options by funds: $242K

107% more first-time investments, than exits

New positions opened: 31 | Existing positions closed: 15

68% more capital invested

Capital invested by funds: $299M → $505M (+$205M)

58% more repeat investments, than reductions

Existing positions increased: 41 | Existing positions reduced: 26

9% more funds holding

Funds holding: 125 → 136 (+11)

4.66% more ownership

Funds ownership: 71.66% → 76.33% (+4.7%)

0% more funds holding in top 10

Funds holding in top 10: 1 → 1 (0)

Holders
136
Holders Change
+11
Holders Change %
+8.8%
% of All Funds
1.67%
Holding in Top 10
1
Holding in Top 10 Change
–
Holding in Top 10 Change %
–
% of All Funds
0.01%
New
31
Increased
41
Reduced
26
Closed
15
Calls
$3.34M
Puts
$242K
Net Calls
+$3.1M
Net Calls Change
+$2.25M

Top Buyers

1
AG
Artal Group
Luxembourg
+$27M
2
SC
Sessa Capital
New York
+$21.7M
3
Point72 Asset Management
Point72 Asset Management
Connecticut
+$11M
4
Fidelity Investments
Fidelity Investments
Massachusetts
+$10.5M
5
SL
Siren LLC
Connecticut
+$7.83M

Top Sellers

1
Citadel Advisors
Citadel Advisors
Florida
-$896K
2
UBS Group
UBS Group
Switzerland
-$762K
3
ECM
ExodusPoint Capital Management
New York
-$336K
4
Acadian Asset Management
Acadian Asset Management
Massachusetts
-$283K
5
OAC
OMERS Administration Corp
Ontario, Canada
-$243K
Name Holding Trade Value Shares
Change 		Change in
Stake
ACM
26
ADAR1 Capital Management
Texas
$1.17M +$1.09M +750,000 New
VPM
27
Vanguard Portfolio Management
Pennsylvania
$853K +$795K +546,600 New
Bank of America
28
Bank of America
North Carolina
$821K +$617K +424,006 +415%
Invesco
29
Invesco
Georgia
$799K -$120K -82,457 -14%
CLOS
30
Compagnie Lombard Odier SCmA
Switzerland
$796K +$145K +100,000 +24%
Northern Trust
31
Northern Trust
Illinois
$772K +$120K +82,502 +20%
Acadian Asset Management
32
Acadian Asset Management
Massachusetts
$693K -$283K -194,842 -30%
TCM
33
Tang Capital Management
California
$624K +$581K +399,700 New
XT
34
XTX Topco
Cayman Islands
$491K +$318K +218,524 +227%
Morgan Stanley
35
Morgan Stanley
New York
$343K +$39K +26,827 +14%
CFM
36
Catalyst Funds Management
Australia
$324K +$244K +167,600 +416%
HT
37
Headlands Technologies
Illinois
$298K +$80.3K +55,209 +41%
Group One Trading
38
Group One Trading
Illinois
$289K -$57.1K -39,302 -18%
Citigroup
39
Citigroup
New York
$260K +$109K +74,728 +82%
IC
40
Ikarian Capital
Texas
$257K – – –
BHCM
41
Brevan Howard Capital Management
Jersey
$250K +$233K +160,499 New
SC
42
Scotia Capital
Ontario, Canada
$249K +$232K +159,831 New
JG
43
Jain Global
New York
$241K +$225K +154,800 New
Hudson Bay Capital Management
44
Hudson Bay Capital Management
Connecticut
$238K +$75.7K +52,084 +52%
Jacobs Levy Equity Management
45
Jacobs Levy Equity Management
New Jersey
$203K +$189K +130,020 New
BA
46
Bridgewater Advisors
New York
$201K +$120K +82,209 New
HF
47
HRT Financial
New York
$191K +$7.61K +5,231 +4%
Cerity Partners
48
Cerity Partners
New York
$172K -$50.1K -34,486 -24%
QC
49
Quadrature Capital
United Kingdom
$172K +$134K +91,965 +499%
QL
50
Quarry LP
New York
$172K +$32K +22,000 +25%
1
2
3 4 5

LXRX Hedge Fund Activity: Q1 2026 in Review

136 of the 8,126 institutional investors tracked by Wall St. Rank reported a position in Lexicon Pharmaceuticals (LXRX) for Q1 2026, worth a combined $505M — up 68% from $299M a quarter earlier.

Buyers outnumbered sellers: 31 funds opened new LXRX positions and 15 closed out — a net gain of 16 holders — while 41 added to existing stakes and 26 trimmed.

The largest buyer was Artal Group, adding an estimated $27M. The largest seller was Citadel Advisors, cutting an estimated $896K.

  • 136 institutional investors held Lexicon Pharmaceuticals (LXRX) as of Q1 2026, up from 125 in Q4 2025.
  • Funds reported $505M of Lexicon Pharmaceuticals stock for Q1 2026, up 68% quarter-over-quarter.
  • 31 funds opened new Lexicon Pharmaceuticals positions in Q1 2026 and 15 closed out, a net change of +16 holders.
  • The largest Lexicon Pharmaceuticals buyer in Q1 2026 was Artal Group, an estimated $27M added.
  • The largest Lexicon Pharmaceuticals seller in Q1 2026 was Citadel Advisors, an estimated $896K sold.

Based on aggregated 13F filings for Q1 2026.