|
1
|
Fidelity Investments
Boston,
Massachusetts
|
$117M
|
-$29.8M
|
-1,579,202
|
-20%
|
|
|
2
|
|
$93.7M
|
+$736K
|
+39,035
|
+0.8%
|
|
|
3
|
Avoro Capital Advisors
New York
|
$74.9M
|
-$2.64M
|
-140,000
|
-3%
|
|
|
4
|
EcoR1 Capital
San Francisco,
California
|
$69.8M
|
–
|
–
|
–
|
|
|
5
|
Vanguard Group
Malvern,
Pennsylvania
|
$61.1M
|
-$267K
|
-14,185
|
-0.4%
|
|
|
6
|
State Street
Boston,
Massachusetts
|
$60.1M
|
-$858K
|
-45,533
|
-1%
|
|
|
7
|
|
$56.2M
|
+$27.8M
|
+1,475,350
|
+97%
|
|
|
8
|
Holocene Advisors
New York
|
$50.8M
|
+$2.39M
|
+126,642
|
+5%
|
|
|
9
|
Suvretta Capital Management
New York
|
$46.1M
|
+$15.1M
|
+801,496
|
+48%
|
|
|
10
|
Ameriprise
Minneapolis,
Minnesota
|
$44.8M
|
-$1.7M
|
-90,225
|
-4%
|
|
|
11
|
Deerfield Management
New York
|
$43.4M
|
+$9.83M
|
+521,417
|
+29%
|
|
|
12
|
Foresite Capital Management IV
Larkspur,
California
|
$34.6M
|
–
|
–
|
–
|
|
|
13
|
BVF Inc
San Francisco,
California
|
$30.6M
|
–
|
–
|
–
|
|
|
14
|
Eventide Asset Management
Boston,
Massachusetts
|
$25.5M
|
+$12.4M
|
+657,044
|
+93%
|
|
|
15
|
Geode Capital Management
Boston,
Massachusetts
|
$20.7M
|
-$874K
|
-46,397
|
-4%
|
|
|
16
|
Boxer Capital
San Diego,
California
|
$19.7M
|
–
|
–
|
–
|
|
|
17
|
|
$19.7M
|
+$8.48M
|
+450,000
|
+75%
|
|
|
18
|
Commodore Capital
New York
|
$18.7M
|
+$7.12M
|
+377,940
|
+61%
|
|
|
19
|
Franklin Resources
San Mateo,
California
|
$18.3M
|
-$45.7K
|
-2,423
|
-0.2%
|
|
|
20
|
Candriam SCA
Strassen, Luxembourg,
Luxembourg
|
$17.7M
|
–
|
–
|
–
|
|
|
21
|
Assenagon Asset Management
Senningerberg,
Luxembourg
|
$15.7M
|
+$5.73M
|
+304,254
|
+57%
|
|
|
22
|
Rock Springs Capital Management
Baltimore,
Maryland
|
$15.4M
|
+$107K
|
+5,700
|
+0.7%
|
|
|
23
|
Eagle Asset Management
St Petersburg,
Florida
|
$15M
|
-$6.76K
|
-359
|
-0%
|
|
|
24
|
Sphera Funds Management
Tel Aviv,
Israel
|
$14.8M
|
-$1.51M
|
-80,151
|
-9%
|
|
|
25
|
Sofinnova Investments
Menlo Park,
California
|
$14.1M
|
+$5.86M
|
+310,749
|
+70%
|
|
