|
1
|
Fidelity Investments
Boston,
Massachusetts
|
$298M
|
+$66M
|
+1,876,852
|
+26%
|
|
|
2
|
|
$161M
|
+$19.3M
|
+547,852
|
+12%
|
|
|
3
|
Avoro Capital Advisors
New York
|
$131M
|
+$55M
|
+1,565,000
|
+64%
|
|
|
4
|
Vanguard Group
Malvern,
Pennsylvania
|
$106M
|
+$19.7M
|
+561,058
|
+21%
|
|
|
5
|
Citadel Advisors
Miami,
Florida
|
$100M
|
+$32.9M
|
+936,627
|
+44%
|
|
|
6
|
State Street
Boston,
Massachusetts
|
$87.4M
|
+$33.2M
|
+946,021
|
+55%
|
|
|
7
|
Foresite Capital Management IV
Larkspur,
California
|
$59M
|
+$17.6M
|
+500,000
|
+38%
|
|
|
8
|
EcoR1 Capital
San Francisco,
California
|
$57.9M
|
-$99.6M
|
-2,835,492
|
-62%
|
|
|
9
|
|
$55.6M
|
+$59.8M
|
+1,701,781
|
New
|
|
|
10
|
Holocene Advisors
New York
|
$52.9M
|
+$12.5M
|
+355,337
|
+28%
|
|
|
11
|
Victory Capital Management
San Antonio,
Texas
|
$50M
|
-$6.09M
|
-173,429
|
-10%
|
|
|
12
|
Wellington Management Group
Boston,
Massachusetts
|
$43.7M
|
+$36.2M
|
+1,030,036
|
+336%
|
|
|
13
|
|
$41M
|
+$22.9M
|
+651,001
|
+108%
|
|
|
14
|
BVF Inc
San Francisco,
California
|
$40.7M
|
-$8.55M
|
-243,200
|
-16%
|
|
|
15
|
Eventide Asset Management
Boston,
Massachusetts
|
$34.6M
|
+$23.2M
|
+660,000
|
+165%
|
|
|
16
|
Ameriprise
Minneapolis,
Minnesota
|
$34.5M
|
+$37.2M
|
+1,057,665
|
New
|
|
|
17
|
Boxer Capital
San Diego,
California
|
$34.3M
|
–
|
–
|
–
|
|
|
18
|
Geode Capital Management
Boston,
Massachusetts
|
$32.5M
|
+$5.65M
|
+160,911
|
+19%
|
|
|
19
|
Candriam SCA
Strassen, Luxembourg,
Luxembourg
|
$30.4M
|
+$13.7M
|
+390,086
|
+72%
|
|
|
20
|
Eagle Asset Management
St Petersburg,
Florida
|
$25.8M
|
-$25.1M
|
-713,487
|
-47%
|
|
|
21
|
Northern Trust
Chicago,
Illinois
|
$24.5M
|
+$2.64M
|
+75,088
|
+11%
|
|
|
22
|
Nuveen
Charlotte,
North Carolina
|
$23.9M
|
-$3.71M
|
-105,583
|
-13%
|
|
|
23
|
Cormorant Asset Management
Boston,
Massachusetts
|
$21.2M
|
+$5.27M
|
+150,000
|
+30%
|
|
|
24
|
HHLR Advisors
Grand Cayman,
Cayman Islands
|
$21.2M
|
+$22.8M
|
+650,000
|
New
|
|
|
25
|
Dimensional Fund Advisors
Austin,
Texas
|
$21.2M
|
+$915K
|
+26,046
|
+4%
|
|
