|
1
|
Fidelity Investments
Boston,
Massachusetts
|
$163M
|
-$34.1M
|
-1,375,494
|
-15%
|
|
|
2
|
|
$103M
|
-$6.48M
|
-261,165
|
-5%
|
|
|
3
|
Avoro Capital Advisors
New York
|
$86.3M
|
+$3.48M
|
+140,000
|
+4%
|
|
|
4
|
EcoR1 Capital
San Francisco,
California
|
$77.7M
|
+$789K
|
+31,800
|
+0.9%
|
|
|
5
|
Vanguard Group
Malvern,
Pennsylvania
|
$68.4M
|
-$1.24M
|
-49,758
|
-1%
|
|
|
6
|
State Street
Boston,
Massachusetts
|
$67.9M
|
+$10.5M
|
+420,992
|
+15%
|
|
|
7
|
Holocene Advisors
New York
|
$54M
|
+$8.6M
|
+346,430
|
+15%
|
|
|
8
|
Ameriprise
Minneapolis,
Minnesota
|
$51.7M
|
+$176K
|
+7,083
|
+0.3%
|
|
|
9
|
Wellington Management Group
Boston,
Massachusetts
|
$44.1M
|
+$10.6M
|
+426,473
|
+25%
|
|
|
10
|
Foresite Capital Management IV
Larkspur,
California
|
$38.6M
|
–
|
–
|
–
|
|
|
11
|
Deerfield Management
New York
|
$37.4M
|
+$44.5M
|
+1,794,000
|
New
|
|
|
12
|
Suvretta Capital Management
New York
|
$34.6M
|
+$23M
|
+926,291
|
+126%
|
|
|
13
|
BVF Inc
San Francisco,
California
|
$34.1M
|
–
|
–
|
–
|
|
|
14
|
|
$31.8M
|
-$4.23M
|
-170,422
|
-10%
|
|
|
15
|
Geode Capital Management
Boston,
Massachusetts
|
$24M
|
+$1.56M
|
+62,700
|
+6%
|
|
|
16
|
Boxer Capital
San Diego,
California
|
$21.9M
|
–
|
–
|
–
|
|
|
17
|
Franklin Resources
San Mateo,
California
|
$20.5M
|
+$5.94M
|
+239,114
|
+32%
|
|
|
18
|
Candriam SCA
Strassen, Luxembourg,
Luxembourg
|
$19.7M
|
+$424K
|
+17,080
|
+2%
|
|
|
19
|
Sphera Funds Management
Tel Aviv,
Israel
|
$18.1M
|
+$3.75M
|
+151,135
|
+21%
|
|
|
20
|
Rock Springs Capital Management
Baltimore,
Maryland
|
$17M
|
+$2.65M
|
+106,765
|
+15%
|
|
|
21
|
Eagle Asset Management
St Petersburg,
Florida
|
$16.7M
|
-$1.09M
|
-43,977
|
-5%
|
|
|
22
|
Two Sigma Investments
New York
|
$16.4M
|
+$4.42M
|
+178,144
|
+29%
|
|
|
23
|
Northern Trust
Chicago,
Illinois
|
$16M
|
+$1.21M
|
+48,766
|
+7%
|
|
|
24
|
Dimensional Fund Advisors
Austin,
Texas
|
$15.9M
|
-$1.46M
|
-58,785
|
-7%
|
|
|
25
|
Eventide Asset Management
Boston,
Massachusetts
|
$14.7M
|
-$22.7M
|
-913,573
|
-56%
|
|
