|
1
|
Fidelity Investments
Boston,
Massachusetts
|
$222M
|
-$18.7M
|
-845,495
|
-10%
|
|
|
2
|
EcoR1 Capital
San Francisco,
California
|
$141M
|
–
|
–
|
–
|
|
|
3
|
|
$134M
|
+$1.03M
|
+46,592
|
+1%
|
|
|
4
|
Vanguard Group
Malvern,
Pennsylvania
|
$81.9M
|
+$29.1K
|
+1,319
|
+0%
|
|
|
5
|
Avoro Capital Advisors
New York
|
$74.6M
|
+$30.6M
|
+1,385,000
|
+132%
|
|
|
6
|
Citadel Advisors
Miami,
Florida
|
$65.3M
|
+$25.4M
|
+1,149,804
|
+117%
|
|
|
7
|
State Street
Boston,
Massachusetts
|
$53M
|
+$1.71M
|
+77,498
|
+5%
|
|
|
8
|
Victory Capital Management
San Antonio,
Texas
|
$52.2M
|
-$7.23M
|
-327,471
|
-16%
|
|
|
9
|
Adage Capital Partners
Boston,
Massachusetts
|
$46M
|
-$6.82M
|
-309,000
|
-17%
|
|
|
10
|
Eagle Asset Management
St Petersburg,
Florida
|
$45.9M
|
-$11.1M
|
-501,002
|
-25%
|
|
|
11
|
BVF Inc
San Francisco,
California
|
$45.6M
|
-$28.4M
|
-1,286,770
|
-46%
|
|
|
12
|
Foresite Capital Management IV
Larkspur,
California
|
$40.1M
|
–
|
–
|
–
|
|
|
13
|
Holocene Advisors
New York
|
$38.7M
|
+$8.2M
|
+371,281
|
+42%
|
|
|
14
|
Carillon Tower Advisers
St. Petersburg,
Florida
|
$35M
|
-$7.94M
|
-359,753
|
-24%
|
|
|
15
|
Boxer Capital
San Diego,
California
|
$32.2M
|
+$4.54M
|
+205,500
|
+24%
|
|
|
16
|
Vivo Capital
Palo Alto,
California
|
$32.2M
|
–
|
–
|
–
|
|
|
17
|
Acuta Capital Partners
Redwood City,
California
|
$29.8M
|
+$2.22M
|
+100,500
|
+12%
|
|
|
18
|
Nuveen
Charlotte,
North Carolina
|
$25.7M
|
+$1.09M
|
+49,476
|
+6%
|
|
|
19
|
Geode Capital Management
Boston,
Massachusetts
|
$25.6M
|
+$2.07M
|
+93,712
|
+13%
|
|
|
20
|
Northern Trust
Chicago,
Illinois
|
$20.7M
|
-$546K
|
-24,742
|
-4%
|
|
|
21
|
Dimensional Fund Advisors
Austin,
Texas
|
$19.1M
|
+$671K
|
+30,369
|
+5%
|
|
|
22
|
Credit Suisse
Zurich,
Switzerland
|
$18.7M
|
+$12.1M
|
+547,762
|
+872%
|
|
|
23
|
|
$18.5M
|
-$605K
|
-27,416
|
-4%
|
|
|
24
|
|
$17.6M
|
–
|
–
|
–
|
|
|
25
|
|
$16.8M
|
-$638K
|
-28,900
|
-5%
|
|
