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Krystal Biotech
KRYS

264 hedge funds and large institutions have $4.35B invested in Krystal Biotech in 2024 Q4 according to their latest regulatory filings, with 37 funds opening new positions, 95 increasing their positions, 97 reducing their positions, and 52 closing their positions.

New
Increased
Maintained
Reduced
Closed

72% more call options, than puts

Call options by funds: $63.3M | Put options by funds: $36.8M

0% more funds holding in top 10

Funds holding in top 10: 6 → 6 (0)

2% less repeat investments, than reductions

Existing positions increased: 95 | Existing positions reduced: 97

1.87% less ownership

Funds ownership: 98.44% → 96.57% (-1.9%)

7% less funds holding

Funds holding: 283 → 264 (-19)

15% less capital invested

Capital invested by funds: $5.15B → $4.35B (-$796M)

29% less first-time investments, than exits

New positions opened: 37 | Existing positions closed: 52

Holders
264
Holders Change
-19
Holders Change %
-6.71%
% of All Funds
3.48%
Holding in Top 10
6
Holding in Top 10 Change
–
Holding in Top 10 Change %
–
% of All Funds
0.08%
New
37
Increased
95
Reduced
97
Closed
52
Calls
$63.3M
Puts
$36.8M
Net Calls
+$26.5M
Net Calls Change
+$3.95M

Top Buyers

Rank Fund Capital Flow
1
SCM
Soleus Capital Management
Connecticut
+$25.1M
2
T. Rowe Price Associates
T. Rowe Price Associates
Maryland
+$12.6M
3
Citigroup
Citigroup
New York
+$11.5M
4
UBS Group
UBS Group
Switzerland
+$11.3M
5
IHAM
Integral Health Asset Management
New York
+$9.76M

Top Sellers

Rank Fund Capital Flow
1
FLSM
Frazier Life Sciences Management
California
-$35.5M
2
State Street
State Street
Massachusetts
-$30.8M
3
Jennison Associates
Jennison Associates
New York
-$18.9M
4
Invesco
Invesco
Georgia
-$16M
5
Allspring Global Investments
Allspring Global Investments
North Carolina
-$14.5M
Name Holding Trade Value Shares
Change 		Change in
Stake
O
76
OrbiMed
New York
$3.68M – – –
New York State Common Retirement Fund
77
New York State Common Retirement Fund
New York
$3.66M -$440K -2,481 -10%
Universal-Beteiligungs- und Servicegesellschaft
78
Universal-Beteiligungs- und Servicegesellschaft
Germany
$3.63M +$4.12M +23,197 New
First Trust Advisors
79
First Trust Advisors
Illinois
$3.63M -$2.88M -16,242 -41%
CM
80
Caption Management
Oklahoma
$3.5M +$3.96M +22,339 New
HF
81
HRT Financial
New York
$3.45M +$3.9M +22,007 New
SEI Investments
82
SEI Investments
Pennsylvania
$3.32M -$2.32M -13,085 -38%
California State Teachers Retirement System (CalSTRS)
83
California State Teachers Retirement System (CalSTRS)
California
$3.19M +$200K +1,127 +6%
Thrivent Financial for Lutherans
84
Thrivent Financial for Lutherans
Minnesota
$3.06M -$51.6K -291 -1%
Millennium Management
85
Millennium Management
New York
$2.97M -$5.09M -28,667 -60%
EAM
86
Erste Asset Management
Austria
$2.9M – – –
EAM
87
EFG Asset Management
Oregon
$2.78M +$742K +4,185 +31%
Wells Fargo
88
Wells Fargo
California
$2.65M +$527K +2,972 +21%
New York State Teachers Retirement System (NYSTRS)
89
New York State Teachers Retirement System (NYSTRS)
New York
$2.49M – – –
Fiera Capital (Canada)
90
Fiera Capital (Canada)
Quebec, Canada
$2.46M -$93.5K -527 -3%
DekaBank Deutsche Girozentrale
91
DekaBank Deutsche Girozentrale
Germany
$2.44M – – –
Mirae Asset Global ETFs Holdings
92
Mirae Asset Global ETFs Holdings
Hong Kong
$2.39M -$32.1K -181 -1%
MIM
93
MetLife Investment Management
New Jersey
$2.35M +$121K +680 +5%
SOADOR
94
State of Alaska Department of Revenue
Alaska
$2.26M -$887 -5 -0%
IMRF
95
Illinois Municipal Retirement Fund
Illinois
$2.22M +$267K +1,505 +12%
HWAM
96
Hennion & Walsh Asset Management
New Jersey
$2.14M -$41.2K -232 -2%
CF
97
Corebridge Financial
Texas
$2.07M -$183K -1,032 -7%
Federated Hermes
98
Federated Hermes
Pennsylvania
$2.04M +$40.6K +229 +2%
Schroder Investment Management Group
99
Schroder Investment Management Group
United Kingdom
$2.01M – – –
LSERS
100
Louisiana State Employees Retirement System
Louisiana
$1.91M – – –
2 3
4
5 6

KRYS Hedge Fund Activity: Q4 2024 in Review

264 of the 7,592 institutional investors tracked by Wall St. Rank reported a position in Krystal Biotech (KRYS) for Q4 2024, worth a combined $4.35B — down 15% from $5.15B a quarter earlier.

Sellers outnumbered buyers: 52 funds closed out of KRYS and 37 opened new positions — a net loss of 15 holders — while 97 trimmed existing stakes and 95 added.

The largest buyer was Soleus Capital Management, adding an estimated $25.1M. The largest seller was Frazier Life Sciences Management, cutting an estimated $35.5M.

  • 264 institutional investors held Krystal Biotech (KRYS) as of Q4 2024, down from 283 in Q3 2024.
  • Funds reported $4.35B of Krystal Biotech stock for Q4 2024, down 15% quarter-over-quarter.
  • 37 funds opened new Krystal Biotech positions in Q4 2024 and 52 closed out, a net change of -15 holders.
  • The largest Krystal Biotech buyer in Q4 2024 was Soleus Capital Management, an estimated $25.1M added.
  • The largest Krystal Biotech seller in Q4 2024 was Frazier Life Sciences Management, an estimated $35.5M sold.

Based on aggregated 13F filings for Q4 2024.