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Krystal Biotech

334 hedge funds and large institutions have $7.02B invested in Krystal Biotech in 2025 Q4 according to their latest regulatory filings, with 82 funds opening new positions, 112 increasing their positions, 104 reducing their positions, and 27 closing their positions.

New
Increased
Maintained
Reduced
Closed

204% more first-time investments, than exits

New positions opened: 82 | Existing positions closed: 27

145% more call options, than puts

Call options by funds: $53M | Put options by funds: $21.6M

42% more capital invested

Capital invested by funds: $4.94B → $7.02B (+$2.08B)

18% more funds holding

Funds holding: 284334 (+50)

14% more funds holding in top 10

Funds holding in top 10: 78 (+1)

1.39% more ownership

Funds ownership: 96.77%98.16% (+1.4%)

8% more repeat investments, than reductions

Existing positions increased: 112 | Existing positions reduced: 104

Holders
334
Holders Change
+50
Holders Change %
+17.61%
% of All Funds
4.06%
Holding in Top 10
8
Holding in Top 10 Change
+1
Holding in Top 10 Change %
+14.29%
% of All Funds
0.1%
New
82
Increased
112
Reduced
104
Closed
27
Calls
$53M
Puts
$21.6M
Net Calls
+$31.3M
Net Calls Change
+$104M
Name Holding Trade Value Shares
Change
Change in
Stake
N
26
Nuveen
North Carolina
$46.6M -$1.74M -8,284 -4%
Marshall Wace
27
Marshall Wace
United Kingdom
$45.3M +$11.5M +54,794 +42%
Principal Financial Group
28
Principal Financial Group
Iowa
$40.7M +$4.68M +22,231 +16%
UBS Group
29
UBS Group
Switzerland
$39.3M +$6.19M +29,422 +23%
Pictet Asset Management
30
Pictet Asset Management
Switzerland
$38.6M -$8.49M -40,336 -20%
Bank of New York Mellon
31
Bank of New York Mellon
New York
$37.3M -$892K -4,240 -3%
WP
32
Woodline Partners
California
$37.1M
JP Morgan Chase
33
JP Morgan Chase
New York
$33.2M -$2.47M -11,730 -8%
Franklin Resources
34
Franklin Resources
California
$31M +$22.3M +105,825 +533%
O
35
OrbiMed
New York
$29.5M +$3.59M +17,055 +17%
Handelsbanken Fonder
36
Handelsbanken Fonder
Sweden
$26.1M +$8.21M +39,000 +58%
VOYA Investment Management
37
VOYA Investment Management
Georgia
$25.5M +$1.97M +9,353 +10%
TCM
38
TimesSquare Capital Management
New York
$24M -$4.44M -21,114 -18%
SST
39
S Squared Technology
New York
$23.7M -$2.74M -13,000 -12%
Public Sector Pension Investment Board (PSP Investments)
40
Public Sector Pension Investment Board (PSP Investments)
Quebec, Canada
$22M -$2.33M -11,069 -11%
CWG
41
C WorldWide Group
Denmark
$21.2M
SBH
42
Segall Bryant & Hamill
Illinois
$20.5M -$425K -2,017 -2%
Corient Private Wealth
43
Corient Private Wealth
Florida
$19M +$7.89M +37,506 +96%
Raymond James Financial
44
Raymond James Financial
Florida
$19M +$2.56M +12,175 +19%
BIA
45
Biondo Investment Advisors
Pennsylvania
$16.8M +$3.42M +16,245 +31%
RhumbLine Advisers
46
RhumbLine Advisers
Massachusetts
$16.4M -$866K -4,116 -6%
Legal & General Group
47
Legal & General Group
United Kingdom
$15.6M -$517K -2,454 -4%
ACM
48
ACT Capital Management
Pennsylvania
$14.9M +$12.7M +60,500 New
Barclays
49
Barclays
United Kingdom
$14.8M -$3.33M -15,834 -21%
Invesco
50
Invesco
Georgia
$14.8M -$1.45M -6,872 -10%