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Krystal Biotech

333 hedge funds and large institutions have $7.02B invested in Krystal Biotech in 2025 Q4 according to their latest regulatory filings, with 81 funds opening new positions, 112 increasing their positions, 104 reducing their positions, and 27 closing their positions.

New
Increased
Maintained
Reduced
Closed

more first-time investments, than exits

New positions opened: | Existing positions closed:

more call options, than puts

Call options by funds: $ | Put options by funds: $

more capital invested

Capital invested by funds: $ → $

more funds holding

Funds holding:

14% more funds holding in top 10

Funds holding in top 10: 78 (+1)

1.39% more ownership

Funds ownership: 96.77%98.16% (+1.4%)

8% more repeat investments, than reductions

Existing positions increased: 112 | Existing positions reduced: 104

Holders
333
Holders Change
Holders Change %
% of All Funds
Holding in Top 10
8
Holding in Top 10 Change
Holding in Top 10 Change %
% of All Funds
New
Increased
Reduced
Closed
Calls
$53M
Puts
$21.6M
Net Calls
Net Calls Change

Top Buyers

1 +$86.1M
2 +$47.8M
3 +$44.1M
4
ACA
Avoro Capital Advisors
New York
+$23.4M
5
Franklin Resources
Franklin Resources
California
+$22.3M

Top Sellers

1 -$67M
2 -$52.7M
3 -$42.1M
4
UBS AM
UBS AM
Illinois
-$35.6M
5
Millennium Management
Millennium Management
New York
-$28.2M
Name Holding Trade Value Shares
Change
Change in
Stake
SEP
326
Signature Equity Partners
Ohio
$493
TC
327
Trust Company
Kansas
$493
FHA
328
Flagship Harbor Advisors
Massachusetts
$493
RS
329
Rakuten Securities
Japan
$247
AWM
330
Abound Wealth Management
Tennessee
$247
Optiver Holding
331
Optiver Holding
Netherlands
$247
KG
332
Kilter Group
New York
$247
RWM
333
Rialto Wealth Management
New York
$247
RAM
334
Readystate Asset Management
Illinois
FCM
335
Fieldview Capital Management
Michigan
AA
336
ALPS Advisors
Colorado
ACP
337
Acuta Capital Partners
California
Schroder Investment Management Group
338
Schroder Investment Management Group
United Kingdom
Connor, Clark & Lunn Investment Management (CC&L)
339
Connor, Clark & Lunn Investment Management (CC&L)
British Columbia, Canada
STA
340
Summit Trail Advisors
New York
DFCM
341
Dark Forest Capital Management
Puerto Rico
OAC
342
OMERS Administration Corp
Ontario, Canada
CP
343
CenterBook Partners
Connecticut
Jane Street
344
Jane Street
New York
SB
345
SIG Brokerage
New York
AACP
346
Advantage Alpha Capital Partners
California
Man Group
347
Man Group
United Kingdom
FGP
348
Freestone Grove Partners
California
LJAC
349
L.J. Altfest & Co
New York
CCIA
350
Campbell & Co Investment Adviser
Maryland