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Ionis Pharmaceuticals

Name Holding Trade Value Shares
Change
Change in
Stake
Fidelity Investments
1
Fidelity Investments
Massachusetts
$1.11B +$2.34M +45,911 +0.2%
Vanguard Group
2
Vanguard Group
Pennsylvania
$639M +$37.6M +738,090 +7%
ClearBridge Investments
3
ClearBridge Investments
New York
$561M +$7.31M +143,380 +1%
Baillie Gifford & Co
4
Baillie Gifford & Co
United Kingdom
$473M -$10.6M -208,099 -2%
BB
5
BB Biotech
Switzerland
$473M +$3.83M +75,000 +0.9%
BlackRock
6
BlackRock
New York
$415M +$10.9M +213,000 +3%
Wellington Management Group
7
Wellington Management Group
Massachusetts
$412M -$85.1M -1,668,160 -18%
WRF
8
Waddell & Reed Financial
Kansas
$189M -$17.1M -334,649 -9%
State Street
9
State Street
Massachusetts
$137M -$24.5M -479,547 -16%
First Trust Advisors
10
First Trust Advisors
Illinois
$120M +$4.85M +95,138 +4%
O
11
OppenheimerFunds
New York
$109M -$2.42M -47,474 -2%
American Century Companies
12
American Century Companies
Missouri
$86.8M +$21.1M +414,255 +35%
Geode Capital Management
13
Geode Capital Management
Massachusetts
$72.5M +$4.19M +82,152 +7%
Goldman Sachs
14
Goldman Sachs
New York
$64.1M -$20.9M -409,723 -26%
T. Rowe Price Associates
15
T. Rowe Price Associates
Maryland
$62.1M +$2.78M +54,588 +5%
Wells Fargo
16
Wells Fargo
California
$61.5M -$1.37M -26,959 -2%
Norges Bank
17
Norges Bank
Norway
$54.5M -$9.98M -195,645 -16%
Bank of America
18
Bank of America
North Carolina
$49.3M +$7.8M +152,844 +20%
PA
19
Pinnacle Associates
New York
$49.1M -$3.12M -61,119 -6%
RJA
20
Raymond James & Associates
Florida
$42.4M -$1.46M -28,609 -4%
DY
21
Dowling & Yahnke
California
$39.4M
Two Sigma Investments
22
Two Sigma Investments
New York
$39.3M +$9.58M +187,876 +35%
EC
23
EcoR1 Capital
California
$39.2M +$33.3M +653,000 +903%
Northern Trust
24
Northern Trust
Illinois
$35M +$335K +6,578 +1%
Morgan Stanley
25
Morgan Stanley
New York
$34.1M +$24.3M +476,560 +311%