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Ionis Pharmaceuticals
IONS

Overview Fund Activity

360 hedge funds and large institutions have $6.67B invested in Ionis Pharmaceuticals in 2025 Q2 according to their latest regulatory filings, with 81 funds opening new positions, 121 increasing their positions, 108 reducing their positions, and 58 closing their positions.

New
Increased
Maintained
Reduced
Closed
Holders
360
Holders Change
+21
Holders Change %
+6.19%
% of All Funds
4.83%
Holding in Top 10
12
Holding in Top 10 Change
+6
Holding in Top 10 Change %
+100%
% of All Funds
0.16%
New
81
Increased
121
Reduced
108
Closed
58
Calls
$65.2M
Puts
$30M
Net Calls
+$35.2M
Net Calls Change
+$29.2M

Top Buyers

1
Adage Capital Partners
Adage Capital Partners
Massachusetts
+$108M
2
Millennium Management
Millennium Management
New York
+$79.6M
3
PCH
Polar Capital Holdings
United Kingdom
+$39.5M
4
Balyasny Asset Management
Balyasny Asset Management
Illinois
+$30.4M
5
WP
Woodline Partners
California
+$29M

Top Sellers

1
Wellington Management Group
Wellington Management Group
Massachusetts
-$81.8M
2
Citadel Advisors
Citadel Advisors
Florida
-$78.4M
3
O
OrbiMed
New York
-$76.6M
4
Invesco
Invesco
Georgia
-$24.4M
5
CCM
Camber Capital Management
Massachusetts
-$21.9M
Name Holding Trade Value Shares
Change 		Shares
Change %
RBI
126
Raiffeisen Bank International
Austria
$2.27M +$600K +15,000 +36%
First Trust Advisors
127
First Trust Advisors
Illinois
$2.23M +$2.23M +56,519 New
PP
128
PDT Partners
New York
$2.15M -$1.65M -41,691 -43%
Ensign Peak Advisors
129
Ensign Peak Advisors
Utah
$2.11M -$70.3K -1,780 -3%
Creative Planning
130
Creative Planning
Kansas
$2.11M +$678K +17,167 +48%
AllianceBernstein
131
AllianceBernstein
Tennessee
$2.06M -$1.92M -48,692 -48%
EAM
132
Erste Asset Management
Austria
$2.04M – – –
CC
133
Capital Counsel
New York
$1.98M +$519K +13,125 +35%
Ohio Public Employees Retirement System (OPERS)
134
Ohio Public Employees Retirement System (OPERS)
Ohio
$1.91M +$2.65K +67 +0.1%
Canada Life
135
Canada Life
Manitoba, Canada
$1.84M +$105K +2,648 +6%
Schroder Investment Management Group
136
Schroder Investment Management Group
United Kingdom
$1.82M – – –
ASRS
137
Arizona State Retirement System
Arizona
$1.74M +$132K +3,353 +8%
Zurich Cantonal Bank
138
Zurich Cantonal Bank
Switzerland
$1.72M +$281K +7,106 +19%
Handelsbanken Fonder
139
Handelsbanken Fonder
Sweden
$1.71M – – –
GIP
140
Granite Investment Partners
California
$1.71M -$998K -25,253 -37%
NSEDCP
141
NJ State Employees Deferred Compensation Plan
New Jersey
$1.66M – – –
GC
142
Guggenheim Capital
Illinois
$1.61M -$22K -557 -1%
Simplex Trading
143
Simplex Trading
Illinois
$1.57M -$985K -24,943 -39%
PCM
144
Prelude Capital Management
New York
$1.56M +$65.2K +1,651 +4%
AG
145
Algert Global
California
$1.51M +$1.51M +38,090 New
William Blair & Company
146
William Blair & Company
Illinois
$1.5M -$19.4K -490 -1%
YIH
147
Y-Intercept (HK)
Hong Kong
$1.49M +$1.49M +37,649 New
GD
148
Grandfield & Dodd
New York
$1.47M -$21K -531 -1%
Mariner
149
Mariner
Kansas
$1.46M +$136K +3,431 +10%
EGM
150
Engineers Gate Manager
New York
$1.31M +$1.31M +33,118 New
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