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Ionis Pharmaceuticals
IONS

Overview Fund Activity

360 hedge funds and large institutions have $6.67B invested in Ionis Pharmaceuticals in 2025 Q2 according to their latest regulatory filings, with 81 funds opening new positions, 121 increasing their positions, 108 reducing their positions, and 58 closing their positions.

New
Increased
Maintained
Reduced
Closed
Holders
360
Holders Change
+21
Holders Change %
+6.19%
% of All Funds
4.83%
Holding in Top 10
12
Holding in Top 10 Change
+6
Holding in Top 10 Change %
+100%
% of All Funds
0.16%
New
81
Increased
121
Reduced
108
Closed
58
Calls
$65.2M
Puts
$30M
Net Calls
+$35.2M
Net Calls Change
+$29.2M

Top Buyers

1
Adage Capital Partners
Adage Capital Partners
Massachusetts
+$108M
2
Millennium Management
Millennium Management
New York
+$79.6M
3
PCH
Polar Capital Holdings
United Kingdom
+$39.5M
4
Balyasny Asset Management
Balyasny Asset Management
Illinois
+$30.4M
5
WP
Woodline Partners
California
+$29M

Top Sellers

1
Wellington Management Group
Wellington Management Group
Massachusetts
-$81.8M
2
Citadel Advisors
Citadel Advisors
Florida
-$78.4M
3
O
OrbiMed
New York
-$76.6M
4
Invesco
Invesco
Georgia
-$24.4M
5
CCM
Camber Capital Management
Massachusetts
-$21.9M
Name Holding Trade Value Shares
Change 		Shares
Change %
Neuberger Berman Group
101
Neuberger Berman Group
New York
$4.53M +$480K +12,150 +12%
HSBC Holdings
102
HSBC Holdings
United Kingdom
$4.29M +$1.33M +33,461 +45%
SEI Investments
103
SEI Investments
Pennsylvania
$3.89M +$1.06M +26,790 +37%
SCM
104
Superstring Capital Management
New York
$3.88M +$3.88M +98,267 New
State of Wisconsin Investment Board
105
State of Wisconsin Investment Board
Wisconsin
$3.82M -$459K -11,622 -11%
DekaBank Deutsche Girozentrale
106
DekaBank Deutsche Girozentrale
Germany
$3.72M – – –
SPS
107
Susquehanna Portfolio Strategies
Pennsylvania
$3.67M +$3.67M +92,900 New
DA
108
DCF Advisers
Connecticut
$3.63M -$128K -3,250 -3%
NWM
109
Nicola Wealth Management
British Columbia, Canada
$3.44M – – –
New York State Common Retirement Fund
110
New York State Common Retirement Fund
New York
$3.44M +$344K +8,711 +11%
Deutsche Bank
111
Deutsche Bank
Germany
$3.37M +$18.5K +468 +0.6%
Manulife (Manufacturers Life Insurance)
112
Manulife (Manufacturers Life Insurance)
Ontario, Canada
$3.29M -$2.13K -54 -0.1%
MG
113
Marex Group
$3.29M +$3.29M +83,361 New
UOC
114
UBS O'Connor
Illinois
$3.21M -$376K -9,528 -10%
WorldQuant Millennium Advisors
115
WorldQuant Millennium Advisors
New York
$2.94M +$2.94M +74,438 New
VanEck Associates
116
VanEck Associates
New York
$2.91M +$2.82M +71,460 +3,313%
Treasurer of the State of North Carolina
117
Treasurer of the State of North Carolina
North Carolina
$2.87M +$39.3K +994 +1%
Walleye Capital
118
Walleye Capital
New York
$2.63M -$1.13M -28,508 -30%
DC
119
Davenport & Co
Virginia
$2.56M +$334K +8,450 +15%
VOYA Investment Management
120
VOYA Investment Management
Georgia
$2.55M +$29.6K +750 +1%
Janus Henderson Group
121
Janus Henderson Group
United Kingdom
$2.52M – – –
Lazard Asset Management
122
Lazard Asset Management
New York
$2.4M -$356 -9 -0%
PFSRSONJ
123
Police & Firemen's Retirement System of New Jersey
New Jersey
$2.36M +$85.9K +2,174 +4%
Skandinaviska Enskilda Banken (SEB)
124
Skandinaviska Enskilda Banken (SEB)
Sweden
$2.36M – – –
State of New Jersey Common Pension Fund D
125
State of New Jersey Common Pension Fund D
New Jersey
$2.33M -$68.9K -1,744 -3%
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5
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