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Ionis Pharmaceuticals
IONS

Overview Fund Activity

360 hedge funds and large institutions have $6.67B invested in Ionis Pharmaceuticals in 2025 Q2 according to their latest regulatory filings, with 81 funds opening new positions, 121 increasing their positions, 108 reducing their positions, and 58 closing their positions.

New
Increased
Maintained
Reduced
Closed
Holders
360
Holders Change
+21
Holders Change %
+6.19%
% of All Funds
4.83%
Holding in Top 10
12
Holding in Top 10 Change
+6
Holding in Top 10 Change %
+100%
% of All Funds
0.16%
New
81
Increased
121
Reduced
108
Closed
58
Calls
$65.2M
Puts
$30M
Net Calls
+$35.2M
Net Calls Change
+$29.2M

Top Buyers

1
Adage Capital Partners
Adage Capital Partners
Massachusetts
+$108M
2
Millennium Management
Millennium Management
New York
+$79.6M
3
PCH
Polar Capital Holdings
United Kingdom
+$39.5M
4
Balyasny Asset Management
Balyasny Asset Management
Illinois
+$30.4M
5
WP
Woodline Partners
California
+$29M

Top Sellers

1
Wellington Management Group
Wellington Management Group
Massachusetts
-$81.8M
2
Citadel Advisors
Citadel Advisors
Florida
-$78.4M
3
O
OrbiMed
New York
-$76.6M
4
Invesco
Invesco
Georgia
-$24.4M
5
CCM
Camber Capital Management
Massachusetts
-$21.9M
Name Holding Trade Value Shares
Change 		Shares
Change %
EDRH
76
Edmond de Rothschild Holding
Switzerland
$7.81M +$2.9M +73,400 +59%
Stifel Financial
77
Stifel Financial
Missouri
$7.76M -$181K -4,585 -2%
TAM
78
Tocqueville Asset Management
New York
$7.4M -$1.98K -50 -0%
SA
79
Sicart Associates
New York
$7.32M -$13.8K -350 -0.2%
RPAM
80
Rhenman & Partners Asset Management
Sweden
$7.19M +$3.99M +101,000 +125%
RhumbLine Advisers
81
RhumbLine Advisers
Massachusetts
$7.17M -$261K -6,617 -4%
BNP Paribas Financial Markets
82
BNP Paribas Financial Markets
France
$7.02M -$5.16M -130,531 -42%
SIMG
83
Sonora Investment Management Group
Arizona
$6.45M +$357K +9,025 +6%
Alyeska Investment Group
84
Alyeska Investment Group
Illinois
$6.28M +$6.28M +159,008 New
ACM
85
Aquatic Capital Management
Illinois
$6.25M +$76.2K +1,929 +1%
State Board of Administration of Florida Retirement System
86
State Board of Administration of Florida Retirement System
Florida
$6.08M +$62.4K +1,580 +1%
BBA
87
BLB&B Advisors
Pennsylvania
$5.99M -$25.7K -650 -0.4%
TCM
88
Tang Capital Management
California
$5.93M – – –
Universal-Beteiligungs- und Servicegesellschaft
89
Universal-Beteiligungs- und Servicegesellschaft
Germany
$5.92M +$236K +5,969 +4%
ACM
90
ADAR1 Capital Management
Texas
$5.87M +$5.87M +148,461 New
JGC
91
J. Goldman & Co
New York
$5.83M -$6.33M -160,088 -52%
California State Teachers Retirement System (CalSTRS)
92
California State Teachers Retirement System (CalSTRS)
California
$5.73M +$508K +12,866 +10%
Rafferty Asset Management
93
Rafferty Asset Management
New York
$5.72M -$1.24M -31,478 -18%
Sumitomo Mitsui Trust Group
94
Sumitomo Mitsui Trust Group
Japan
$5.52M -$106K -2,694 -2%
NAMA
95
Nikko Asset Management Americas
New York
$5.52M -$106K -2,694 -2%
Squarepoint
96
Squarepoint
New York
$5.31M -$6.76M -170,978 -56%
KCM
97
Kennedy Capital Management
Missouri
$5.22M -$726K -18,379 -12%
TI
98
Trexquant Investment
Connecticut
$5.09M +$5.09M +128,869 New
EAM
99
Exome Asset Management
New York
$4.79M -$573K -14,500 -11%
Healthcare of Ontario Pension Plan (HOOPP) Trust Fund
100
Healthcare of Ontario Pension Plan (HOOPP) Trust Fund
Ontario, Canada
$4.58M +$4.58M +116,000 New
2 3
4
5 6