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Ionis Pharmaceuticals
IONS

Overview Fund Activity

360 hedge funds and large institutions have $6.67B invested in Ionis Pharmaceuticals in 2025 Q2 according to their latest regulatory filings, with 81 funds opening new positions, 121 increasing their positions, 108 reducing their positions, and 58 closing their positions.

New
Increased
Maintained
Reduced
Closed
Holders
360
Holders Change
+21
Holders Change %
+6.19%
% of All Funds
4.83%
Holding in Top 10
12
Holding in Top 10 Change
+6
Holding in Top 10 Change %
+100%
% of All Funds
0.16%
New
81
Increased
121
Reduced
108
Closed
58
Calls
$65.2M
Puts
$30M
Net Calls
+$35.2M
Net Calls Change
+$29.2M

Top Buyers

1
Adage Capital Partners
Adage Capital Partners
Massachusetts
+$108M
2
Millennium Management
Millennium Management
New York
+$79.6M
3
PCH
Polar Capital Holdings
United Kingdom
+$39.5M
4
Balyasny Asset Management
Balyasny Asset Management
Illinois
+$30.4M
5
WP
Woodline Partners
California
+$29M

Top Sellers

1
Wellington Management Group
Wellington Management Group
Massachusetts
-$81.8M
2
Citadel Advisors
Citadel Advisors
Florida
-$78.4M
3
O
OrbiMed
New York
-$76.6M
4
Invesco
Invesco
Georgia
-$24.4M
5
CCM
Camber Capital Management
Massachusetts
-$21.9M
Name Holding Trade Value Shares
Change 		Shares
Change %
Bank of America
26
Bank of America
North Carolina
$39.3M +$9.03M +228,458 +30%
AIM
27
ARK Investment Management
Florida
$35.6M -$3.96M -100,209 -10%
Voloridge Investment Management
28
Voloridge Investment Management
Florida
$33.8M +$18.9M +477,430 +127%
Northern Trust
29
Northern Trust
Illinois
$32.2M -$814K -20,597 -2%
Royal Bank of Canada
30
Royal Bank of Canada
Ontario, Canada
$31.6M +$7.26M +183,831 +30%
UBS AM
31
UBS AM
Illinois
$31.3M +$5.2M +131,637 +20%
Goldman Sachs
32
Goldman Sachs
New York
$30.7M +$4.96M +125,422 +19%
Balyasny Asset Management
33
Balyasny Asset Management
Illinois
$30.4M +$30.4M +768,648 New
Hudson Bay Capital Management
34
Hudson Bay Capital Management
Connecticut
$29.6M -$11.8M -299,900 -29%
WP
35
Woodline Partners
California
$29M +$29M +732,813 New
CS
36
Candriam SCA
Luxembourg
$28.6M -$10.6M -268,964 -27%
GAM
37
Groupama Asset Management
France
$26.8M +$3.72M +91,746 +16%
Teacher Retirement System of Texas
38
Teacher Retirement System of Texas
Texas
$26.4M +$6.63M +167,822 +34%
Pictet Asset Management
39
Pictet Asset Management
Switzerland
$24.2M -$394K -9,910 -2%
EP
40
Eversept Partners
New York
$23.3M +$2.84M +71,879 +14%
Barclays
41
Barclays
United Kingdom
$23M +$9.06M +229,329 +65%
Axa
42
Axa
France
$22.4M +$15.7K +397 +0.1%
Bank of New York Mellon
43
Bank of New York Mellon
New York
$20.8M -$689K -17,445 -3%
Massachusetts Financial Services
44
Massachusetts Financial Services
Massachusetts
$20.5M +$20.5M +519,184 New
GPP
45
Great Point Partners
Connecticut
$19.8M +$9.88M +250,000 +100%
VPC
46
Vestal Point Capital
New York
$19.8M +$19.8M +500,000 New
PA
47
Pinnacle Associates
New York
$19.5M -$4.5M -113,978 -19%
Bank of Montreal
48
Bank of Montreal
Ontario, Canada
$19.1M -$11.8M -299,546 -38%
American Century Companies
49
American Century Companies
Missouri
$18.7M +$14.1M +355,981 +305%
Norges Bank
50
Norges Bank
Norway
$17.8M +$17.8M +450,254 New
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