Ionis Pharmaceuticals
      
      
        
          IONS
        
        
      
    
  
          IONS
        
        
      339 hedge funds and large institutions have $5.01B invested in Ionis Pharmaceuticals in 2025 Q1 according to their latest regulatory filings, with 54 funds opening new positions, 102 increasing their positions, 122 reducing their positions, and 61 closing their positions.
New
  Increased
  Maintained
  Reduced
  Closed
  more funds holding in top 10
Funds holding in top 10: →
more call options, than puts
Call options by funds: $ | Put options by funds: $
more ownership
Funds ownership: →
less funds holding
Funds holding: →
11% less capital invested
Capital invested by funds: $5.61B → $5.01B (-$606M)
11% less first-time investments, than exits
New positions opened: 54 | Existing positions closed: 61
16% less repeat investments, than reductions
Existing positions increased: 102 | Existing positions reduced: 122
    
      Holders
    
  
  
    
      
        
      
        339
      
    
      
    
  
    
      Holding in Top 10
    
  
  
    
      
        
      
        6
      
    
      
    
  
    
      Calls
    
  
  
    
      
        
      
        $24.8M
      
    
      
    
  
    
      Puts
    
  
  
    
      
        
      
        $18.8M
      
    
      
    
  
Top Buyers
| 1 | +$79.4M | |
| 2 | +$60.5M | |
| 3 | +$57.7M | |
| 4 | 
      Citadel Advisors
     
      
        Miami,
      
      
        Florida
      
     | +$39.6M | 
| 5 |   
      Fidelity Investments
     
      
        Boston,
      
      
        Massachusetts
      
     | +$27.9M | 
Top Sellers
| 1 | -$56.6M | |
| 2 | -$24.2M | |
| 3 | -$20.8M | |
| 4 | 
      State Street
     
      
        Boston,
      
      
        Massachusetts
      
     | -$17.5M | 
| 5 | 
      T. Rowe Price Associates
     
      
        Baltimore,
      
      
        Maryland
      
     | -$17M |