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Ionis Pharmaceuticals
IONS

Overview Fund Activity

360 hedge funds and large institutions have $6.67B invested in Ionis Pharmaceuticals in 2025 Q2 according to their latest regulatory filings, with 81 funds opening new positions, 121 increasing their positions, 108 reducing their positions, and 58 closing their positions.

New
Increased
Maintained
Reduced
Closed
Holders
360
Holders Change
+21
Holders Change %
+6.19%
% of All Funds
4.83%
Holding in Top 10
12
Holding in Top 10 Change
+6
Holding in Top 10 Change %
+100%
% of All Funds
0.16%
New
81
Increased
121
Reduced
108
Closed
58
Calls
$65.2M
Puts
$30M
Net Calls
+$35.2M
Net Calls Change
+$29.2M

Top Buyers

1
Adage Capital Partners
Adage Capital Partners
Massachusetts
+$108M
2
Millennium Management
Millennium Management
New York
+$79.6M
3
PCH
Polar Capital Holdings
United Kingdom
+$39.5M
4
Balyasny Asset Management
Balyasny Asset Management
Illinois
+$30.4M
5
WP
Woodline Partners
California
+$29M

Top Sellers

1
Wellington Management Group
Wellington Management Group
Massachusetts
-$81.8M
2
Citadel Advisors
Citadel Advisors
Florida
-$78.4M
3
O
OrbiMed
New York
-$76.6M
4
Invesco
Invesco
Georgia
-$24.4M
5
CCM
Camber Capital Management
Massachusetts
-$21.9M
Name Holding Trade Value Shares
Change 		Shares
Change %
CIR
326
Clear Investment Research
Georgia
$2.81K +$790 +20 +39%
WA
327
WPG Advisers
Maryland
$2.77K +$2.77K +70 New
PWMG
328
Private Wealth Management Group
New Jersey
$2.57K +$1.94K +49 +306%
PS
329
Principal Securities
Iowa
$2.49K -$158 -4 -6%
BIA
330
Bell Investment Advisors
California
$2.41K -$395 -10 -14%
ADL
331
Asset Dedication LLC
California
$2.33K +$2.33K +59 New
SC
332
SouthState Corp
Florida
$2.02K -$2.69K -68 -57%
Bessemer Group
333
Bessemer Group
New Jersey
$2K -$1.74K -34 -47%
CA
334
CoreCap Advisors
Michigan
$1.78K -$277 -7 -13%
S
335
Sachetta
Massachusetts
$1.78K +$1.15K +29 +181%
TPCW
336
TD Private Client Wealth
New York
$1.74K +$1.74K +44 New
HWP
337
Highline Wealth Partners
California
$1.5K – – –
RF
338
Rossby Financial
Florida
$1.34K +$1.34K +34 New
CVM
339
Cheviot Value Management
California
$1.17K – – –
HWM
340
Hemington Wealth Management
Virginia
$1K -$318 -14 -24%
HFS
341
Hantz Financial Services
Michigan
$1K +$1K +36 New
PWA
342
Principia Wealth Advisory
Texas
$988 +$988 +25 New
BGAI
343
Bruce G. Allen Investments
Colorado
$909 +$395 +10 +77%
TFM
344
TFC Financial Management
Massachusetts
$830 – – –
KFI
345
Key Financial Inc
Pennsylvania
$751 – – –
CH
346
Cromwell Holdings
Wyoming
$711 +$711 +18 New
FFO
347
Fortitude Family Office
Arizona
$672 +$672 +17 New
GRP
348
Global Retirement Partners
California
$632 +$632 +16 New
HI
349
Horizon Investments
North Carolina
$593 +$593 +15 New
QWM
350
Quaker Wealth Management
New Jersey
$554 +$554 +14 New
12 13
14
15 16