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566 hedge funds and large institutions have $30.3B invested in Insmed in 2025 Q3 according to their latest regulatory filings, with 130 funds opening new positions, 194 increasing their positions, 197 reducing their positions, and 72 closing their positions.

New
Increased
Maintained
Reduced
Closed

81% more first-time investments, than exits

New positions opened: 130 | Existing positions closed: 72

43% more capital invested

Capital invested by funds: $21.2B → $30.3B (+$9.17B)

10% more funds holding

Funds holding: 516566 (+50)

2% less repeat investments, than reductions

Existing positions increased: 194 | Existing positions reduced: 197

7% less call options, than puts

Call options by funds: $610M | Put options by funds: $657M

15.75% less ownership

Funds ownership: 115.51%99.76% (-16%)

27% less funds holding in top 10

Funds holding in top 10: 3324 (-9)

Holders
566
Holders Change
+50
Holders Change %
+9.69%
% of All Funds
7.43%
Holding in Top 10
24
Holding in Top 10 Change
-9
Holding in Top 10 Change %
-27.27%
% of All Funds
0.32%
New
130
Increased
194
Reduced
197
Closed
72
Calls
$610M
Puts
$657M
Net Calls
-$47.7M
Net Calls Change
+$8.54M
Name Holding Trade Value Shares
Change
Change in
Stake
Assenagon Asset Management
126
Assenagon Asset Management
Luxembourg
$18.6M +$6.84M +55,841 +76%
Los Angeles Capital Management
127
Los Angeles Capital Management
California
$18.4M -$24.9M -203,297 -61%
WP
128
Woodline Partners
California
$18.2M -$15M -122,659 -49%
Barclays
129
Barclays
United Kingdom
$16.4M -$9.15M -74,668 -40%
JFG
130
Jefferies Financial Group
New York
$15.6M +$12.6M +103,114 +2,069%
AI
131
Axiom Investors
Connecticut
$15.5M +$5.76M +46,992 +77%
LPL Financial
132
LPL Financial
California
$15.4M +$4.35M +35,526 +50%
VanEck Associates
133
VanEck Associates
New York
$15.4M -$1.6M -13,084 -11%
SI
134
Sofinnova Investments
California
$15M -$25.7M -209,584 -67%
DCM
135
Driehaus Capital Management
Illinois
$14.3M -$1.08M -8,780 -8%
ACM
136
Atika Capital Management
New York
$13.7M +$11.6M +95,000 New
FAM
137
Fred Alger Management
New York
$13.5M -$11.7M -95,686 -50%
LP
138
LMR Partners
United Kingdom
$13.5M +$3.05M +24,912 +36%
RA
139
Royce & Associates
New York
$13.3M +$288K +2,349 +3%
Bank of Montreal
140
Bank of Montreal
Ontario, Canada
$13.2M +$7.61M +62,081 +209%
EAM
141
EULAV Asset Management
Florida
$13M +$11M +90,000 New
EIM
142
Essex Investment Management
Massachusetts
$12.5M +$2.54M +20,732 +31%
Man Group
143
Man Group
United Kingdom
$12.3M +$10.4M +85,169 New
Treasurer of the State of North Carolina
144
Treasurer of the State of North Carolina
North Carolina
$12.1M +$44.3K +362 +0.4%
PFSRSONJ
145
Police & Firemen's Retirement System of New Jersey
New Jersey
$11.9M +$1.79M +14,611 +22%
Citigroup
146
Citigroup
New York
$11.5M -$804K -6,562 -8%
RHJA
147
Rice Hall James & Associates
California
$11.5M -$870K -7,103 -8%
TI
148
Trexquant Investment
Connecticut
$11.1M +$182K +1,488 +2%
American Century Companies
149
American Century Companies
Missouri
$11M -$13.9M -113,385 -60%
ACM
150
Aquatic Capital Management
Illinois
$11M -$15.1M -123,591 -62%

INSM Hedge Fund Activity: Q3 2025 in Review

566 of the 7,619 institutional investors tracked by Wall St. Rank reported a position in Insmed (INSM) for Q3 2025, worth a combined $30.3B — up 43% from $21.2B a quarter earlier.

Buyers outnumbered sellers: 130 funds opened new INSM positions and 72 closed out — a net gain of 58 holders — while 194 added to existing stakes and 197 trimmed.

The largest buyer was JP Morgan Chase, adding an estimated $908M. The largest seller was T. Rowe Price Associates, cutting an estimated $527M.

  • 566 institutional investors held Insmed (INSM) as of Q3 2025, up from 516 in Q2 2025.
  • Funds reported $30.3B of Insmed stock for Q3 2025, up 43% quarter-over-quarter.
  • 130 funds opened new Insmed positions in Q3 2025 and 72 closed out, a net change of +58 holders.
  • The largest Insmed buyer in Q3 2025 was JP Morgan Chase, an estimated $908M added.
  • The largest Insmed seller in Q3 2025 was T. Rowe Price Associates, an estimated $527M sold.

Based on aggregated 13F filings for Q3 2025.