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516 hedge funds and large institutions have $21.2B invested in Insmed in 2025 Q2 according to their latest regulatory filings, with 131 funds opening new positions, 165 increasing their positions, 189 reducing their positions, and 52 closing their positions.

New
Increased
Maintained
Reduced
Closed

152% more first-time investments, than exits

New positions opened: 131 | Existing positions closed: 52

38% more capital invested

Capital invested by funds: $15.3B → $21.2B (+$5.85B)

17% more funds holding

Funds holding: 441516 (+75)

6% more funds holding in top 10

Funds holding in top 10: 3133 (+2)

5.23% more ownership

Funds ownership: 110.29%115.51% (+5.2%)

13% less repeat investments, than reductions

Existing positions increased: 165 | Existing positions reduced: 189

16% less call options, than puts

Call options by funds: $300M | Put options by funds: $356M

Holders
516
Holders Change
+75
Holders Change %
+17.01%
% of All Funds
6.79%
Holding in Top 10
33
Holding in Top 10 Change
+2
Holding in Top 10 Change %
+6.45%
% of All Funds
0.43%
New
131
Increased
165
Reduced
189
Closed
52
Calls
$300M
Puts
$356M
Net Calls
-$56.3M
Net Calls Change
+$15.7M
Name Holding Trade Value Shares
Change
Change in
Stake
Wells Fargo
101
Wells Fargo
California
$26.1M +$4.11M +53,696 +26%
Healthcare of Ontario Pension Plan (HOOPP) Trust Fund
102
Healthcare of Ontario Pension Plan (HOOPP) Trust Fund
Ontario, Canada
$25.2M +$19.1M +250,100 New
SCM
103
Silverarc Capital Management
Massachusetts
$25.1M -$5.53M -72,306 -22%
WP
104
Woodline Partners
California
$25.1M +$11.5K +151 +0.1%
SCM
105
Suvretta Capital Management
New York
$24M -$95.9M -1,253,600 -84%
Russell Investments Group
106
Russell Investments Group
United Kingdom
$23.6M -$5.23M -68,379 -23%
Comerica Bank
107
Comerica Bank
Texas
$23.4M -$4.43M -57,876 -20%
Axa
108
Axa
France
$22.8M +$1.74M +22,746 +11%
Manulife (Manufacturers Life Insurance)
109
Manulife (Manufacturers Life Insurance)
Ontario, Canada
$22.8M -$7.04M -92,127 -29%
Connor, Clark & Lunn Investment Management (CC&L)
110
Connor, Clark & Lunn Investment Management (CC&L)
British Columbia, Canada
$22.8M +$16.1M +210,999 +1,393%
YIH
111
Y-Intercept (HK)
Hong Kong
$22.6M +$17.2M +224,302 New
California Public Employees Retirement System
112
California Public Employees Retirement System
California
$22.4M -$3.31M -43,241 -16%
Susquehanna International Group
113
Susquehanna International Group
Pennsylvania
$21.4M -$18.1M -236,392 -53%
CM
114
Caption Management
Oklahoma
$21.2M +$16.1M +210,928 New
Squarepoint
115
Squarepoint
New York
$21.2M +$16.1M +210,647 New
RhumbLine Advisers
116
RhumbLine Advisers
Massachusetts
$21M -$7.28M -95,212 -31%
Legal & General Group
117
Legal & General Group
United Kingdom
$20.9M +$2.11M +27,649 +15%
SPS
118
Susquehanna Portfolio Strategies
Pennsylvania
$20.9M +$15.9M +207,527 New
BHCM
119
Brevan Howard Capital Management
Jersey
$20.4M +$15.5M +202,594 New
Deutsche Bank
120
Deutsche Bank
Germany
$20.3M -$8.33M -108,983 -35%
TCM
121
Tang Capital Management
California
$20.1M +$7.65M +100,000 +100%
ACM
122
Aquatic Capital Management
Illinois
$20.1M +$9.66M +126,320 +172%
NIP
123
Nicholas Investment Partners
California
$19.7M -$2.18M -28,537 -13%
American Century Companies
124
American Century Companies
Missouri
$19.1M -$52.2M -682,059 -78%
FAM
125
Fred Alger Management
New York
$19.1M -$14.4M -188,612 -50%

INSM Hedge Fund Activity: Q2 2025 in Review

516 of the 7,595 institutional investors tracked by Wall St. Rank reported a position in Insmed (INSM) for Q2 2025, worth a combined $21.2B — up 38% from $15.3B a quarter earlier.

Buyers outnumbered sellers: 131 funds opened new INSM positions and 52 closed out — a net gain of 79 holders — while 165 added to existing stakes and 189 trimmed.

The largest buyer was JP Morgan Chase, adding an estimated $710M. The largest seller was BlackRock, cutting an estimated $375M.

  • 516 institutional investors held Insmed (INSM) as of Q2 2025, up from 441 in Q1 2025.
  • Funds reported $21.2B of Insmed stock for Q2 2025, up 38% quarter-over-quarter.
  • 131 funds opened new Insmed positions in Q2 2025 and 52 closed out, a net change of +79 holders.
  • The largest Insmed buyer in Q2 2025 was JP Morgan Chase, an estimated $710M added.
  • The largest Insmed seller in Q2 2025 was BlackRock, an estimated $375M sold.

Based on aggregated 13F filings for Q2 2025.